SR-0813
- 1 lab in 1 country
- Funders: Chiang Mai University and 4 more
- Model organisms2
Outcomes
5Lifespan
upin flies2
2 studies
Lifespan
upin flies2
SR-0813 extends lifespan in flies.
“SR-0813 phenocopied ENL/AF9 knockdown by extending lifespan and enhancing stress tolerance.”
Model organismsnormative conditions
Context-dependent YEATS-domain inhibition enhances neuronal resilience and improves ALS phenotypes
Neurobiology of disease27 Jul 2026
SR-0813 extends lifespan in flies.
“SR-0813 phenocopies genetic ENL/AF9 reduction by extending lifespan and enhancing stress tolerance in vivo”
Model organisms
bioRxiv (Cold Spring Harbor Laboratory)13 Apr 2026Preprint
Integrated stress response
downin human cells1
1 study
Integrated stress response
downin human cells1
SR-0813 inhibits integrated stress response in human cells.
“ENL/AF9 YEATS inhibition dampened PERK-dependent integrated stress response signaling and reduced apoptotic commitment”
Cellsendoplasmic reticulum stress
Context-dependent YEATS-domain inhibition enhances neuronal resilience and improves ALS phenotypes
Neurobiology of disease27 Jul 2026
Survival
upin human cells1
1 study
Survival
upin human cells1
SR-0813 improves survival in human cells.
“In human neurons, SR-0813 improved survival across multiple stress conditions, with the strongest protection during endoplasmic reticulum stress.”
Cellsmultiple stress conditions, strongest in endoplasmic reticulum stress
Context-dependent YEATS-domain inhibition enhances neuronal resilience and improves ALS phenotypes
Neurobiology of disease27 Jul 2026
Neuronal survival
upin human cells1
1 study
Neuronal survival
upin human cells1
SR-0813 increases neuronal survival in human cells.
“improves survival of human neurons under multiple stress conditions, with the strongest effects during endoplasmic reticulum stress.”
Cellsmultiple stress conditions, with strongest effects during endoplasmic reticulum stressneuron
bioRxiv (Cold Spring Harbor Laboratory)13 Apr 2026Preprint
Hydrogen peroxide tolerance
upin flies1
1 study
Hydrogen peroxide tolerance
upin flies1
SR-0813 improves hydrogen peroxide tolerance in flies.
“siRNA or the YEATS-domain inhibitor SR-0813 suppress the acyl-lysine reader ENL/AF9, extending lifespan and increasing H2O2 tolerance in Drosophila”
Model organismshydrogen peroxide stress
bioRxiv (Cold Spring Harbor Laboratory)13 Apr 2026Preprint