Sotagliflozin
InterventionSGLT2 inhibitors2 papers6 findingsPubChem 24831714ChEBI 229226
- In silico1
Outcomes
4Cardiovascular events
downin humans1
1 study
Cardiovascular events
downin humans1
Sotagliflozin decreases cardiovascular events in humans.
Reviewtype 2 diabetes and recent worsening heart failure
Cost-Effectiveness of Sotagliflozin in Heart Failure Patients with Preserved and Reduced Ejection Fractions - Results from SOLOIST-WHF · The American journal of cardiology · 30 Sep 2026
Quality-adjusted life-years
upin silico1Very low certainty
1 study
Quality-adjusted life-years
upin silico1Very low certainty
Sotagliflozin improves quality-adjusted life-years in silico (0.39 QALYs (4.43 vs. 4.04)).
In silicodiabetes and recent worsening heart failure
Cost-Effectiveness of Sotagliflozin in Heart Failure Patients with Preserved and Reduced Ejection Fractions - Results from SOLOIST-WHF · The American journal of cardiology · 30 Sep 2026
Lifespan
upin silico1Very low certainty
1 study
Lifespan
upin silico1Very low certainty
Sotagliflozin extends lifespan in silico (0.64 life-years (7.12 vs. 6.48)).
In silicodiabetes and recent worsening heart failure
Cost-Effectiveness of Sotagliflozin in Heart Failure Patients with Preserved and Reduced Ejection Fractions - Results from SOLOIST-WHF · The American journal of cardiology · 30 Sep 2026
Liver injury
no changein humans1
1 study
Liver injury
no changein humans1
Sotagliflozin has no effect on liver injury in humans.
Review
Sotagliflozin · National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda (MD) · 19 Sep 2026
Associations
2Heart failure
downin humans1
1 study
Heart failure
downin humans1
Sotagliflozin lowers the risk of heart failure in humans.
Reviewadults with heart failure or with type 2 diabetes and chronic kidney disease
Sotagliflozin · National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda (MD) · 19 Sep 2026
Cardiovascular death
downin humans1
1 study
Cardiovascular death
downin humans1
Sotagliflozin lowers the risk of cardiovascular death in humans.
Reviewadults with heart failure or with type 2 diabetes and chronic kidney disease
Sotagliflozin · National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda (MD) · 19 Sep 2026