Sotagliflozin

InterventionSGLT2 inhibitors2 papers6 findingsPubChem 24831714ChEBI 229226

  • In silico1

Outcomes

4

Cardiovascular events

downin humans1

1 study
  1. Sotagliflozin decreases cardiovascular events in humans.

    Reviewtype 2 diabetes and recent worsening heart failure

    Cost-Effectiveness of Sotagliflozin in Heart Failure Patients with Preserved and Reduced Ejection Fractions - Results from SOLOIST-WHF · The American journal of cardiology · 30 Sep 2026

Quality-adjusted life-years

upin silico1Very low certainty

1 study
  1. Sotagliflozin improves quality-adjusted life-years in silico (0.39 QALYs (4.43 vs. 4.04)).

    In silicodiabetes and recent worsening heart failure

    Cost-Effectiveness of Sotagliflozin in Heart Failure Patients with Preserved and Reduced Ejection Fractions - Results from SOLOIST-WHF · The American journal of cardiology · 30 Sep 2026

Lifespan

upin silico1Very low certainty

1 study
  1. Sotagliflozin extends lifespan in silico (0.64 life-years (7.12 vs. 6.48)).

    In silicodiabetes and recent worsening heart failure

    Cost-Effectiveness of Sotagliflozin in Heart Failure Patients with Preserved and Reduced Ejection Fractions - Results from SOLOIST-WHF · The American journal of cardiology · 30 Sep 2026

Liver injury

no changein humans1

1 study
  1. Sotagliflozin has no effect on liver injury in humans.

    Review

    Sotagliflozin · National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda (MD) · 19 Sep 2026

Liver injury →

Associations

2

Heart failure

downin humans1

1 study
  1. Sotagliflozin lowers the risk of heart failure in humans.

    Reviewadults with heart failure or with type 2 diabetes and chronic kidney disease

    Sotagliflozin · National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda (MD) · 19 Sep 2026

Heart failure →

Cardiovascular death

downin humans1

1 study
  1. Sotagliflozin lowers the risk of cardiovascular death in humans.

    Reviewadults with heart failure or with type 2 diabetes and chronic kidney disease

    Sotagliflozin · National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda (MD) · 19 Sep 2026

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 2Oct 2026: 02
National Institute of Diabetes and Digestive and Kidney Diseases, BethesdaReview

Sotagliflozin