Social disadvantage

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: National Natural Science Foundation of China and 2 more

Humans2

Associations

Mortality

upin humans1HR 1.13

1 study

Social disadvantage raises the risk of mortality in humans (HR = 1.13; 95% CI: 1.07-1.19).
“Among women, each additional year spent in social disadvantage at age 50 was associated with a 13% higher mortality hazard (HR = 1.13; 95% CI: 1.07-1.19).”
Humansper each additional year spent in social disadvantagefemales
Sex differences in life-course social disadvantage and all-cause mortality: evidence from a longitudinal study from 1996 to 2023
BMC public health3 Aug 2026

Accelerated phenotypic aging

upin humans1OR 1.41

1 study

Social disadvantage is associated with accelerated phenotypic aging in humans (OR 1.41, 95% CI 1.08-1.83, P = 0.013).
“social disadvantage was significantly associated with a 41 % increased risk of accelerated phenotypic aging (OR = 1.41, 95 % CI: 1.08-1.83, P = 0.013).”
Humansn = 5,747
Dietary inflammatory index and depressive symptoms as mediators between social disadvantage and accelerated phenotypic aging
Journal of affective disorders30 Jul 2025