DNAm PAI-1

1. SHBG is associated with DNAm PAI-1 in humans (-478 pg/mL per 1 SD (95% CI -614 to -343)).

   “Sex Hormone Binding Globulin (SHBG) was associated with a decrease in DNAm PAI1 among men (per 1 standard deviation (SD): -478 pg/mL; 95%CI: -614 to -343; P:1e-11; BH-P: 1e-10)”

   Humansmales

   Higher testosterone and testosterone/estradiol ratio in men are associated with decreased Pheno-/GrimAge and DNA-methylation based PAI1

   GeroScience·27 Jun 2023

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1. Testosterone/estradiol ratio is associated with DNAm PAI-1 in humans (-351 pg/mL (95% CI -486 to -217)).

   “and DNAm PAI1 (-351 pg/mL; 95%CI: -486 to -217; P:4e-7; BH-P:3e-6) among men.”

   Humansmales

   Higher testosterone and testosterone/estradiol ratio in men are associated with decreased Pheno-/GrimAge and DNA-methylation based PAI1

   GeroScience·27 Jun 2023

More on Testosterone/estradiol ratio

1. Testosterone is associated with DNAm PAI-1 in humans (-481 pg/mL (95% CI -613 to -349)).

   “In men, testosterone was associated with a decrease in DNAm PAI1 (-481 pg/mL; 95%CI: -613 to -349; P:2e-12; BH-P:6e-11).”

   Humansmales

   Higher testosterone and testosterone/estradiol ratio in men are associated with decreased Pheno-/GrimAge and DNA-methylation based PAI1

   GeroScience·27 Jun 2023

More on Testosterone

1. DNAm PAI-1 is associated with visceral fat in humans (r = 0.41, P = 4.7x10−41).

   “DNAm PAI-1 outperforms the other age-adjusted DNAm biomarkers including GrimAge2 in correlating with triglyceride (cor=0.34, P=9.6x10−267) and visceral fat (cor=0.41, P=4.7x10−41).”

   Humansblood

   DNA methylation GrimAge version 2

   Aging·14 Dec 2022

More on Visceral fat

1. DNAm PAI-1 is associated with birthweight in humans.

   “DNAm PAI-1, b(SE) = - .079(.031), p = .013; DNAm ADM, b(SE) = - 13.8 (3.87), p = .001; and DNAm cystatin C, b(SE) = - .010 (.003), p = .001, were also associated with lower birthweight”

   Humanswhole bloodfemalesn = 77

   Epigenetic age and pregnancy outcomes: GrimAge acceleration is associated with shorter gestational length and lower birthweight

   Clinical epigenetics·6 Aug 2020

1. DNAm PAI-1 is associated with gestational length in humans.

   “DNAm PAI-1, b(SE) = - 1.95 × 10−4 (8.5 × 10−5), p = .004; DNAm ADM, b(SE) = - .033 (.011), p = .003; and DNAm cystatin C, b(SE) = 2.10 × 10−5 (8.0 × 10−5), p = .012, were each associated with shorter gestational length.”

   Humanswhole bloodfemalesn = 77

   Epigenetic age and pregnancy outcomes: GrimAge acceleration is associated with shorter gestational length and lower birthweight

   Clinical epigenetics·6 Aug 2020

1. DNAm PAI-1 is associated with type 2 diabetes in humans (P=2.0E-26).

   “age-adjusted DNAm PAI-1 levels are associated with lifespan (P=5.4E-28), comorbidity count (P= 7.3E-56) and type 2 diabetes (P=2.0E-26)”

   Humans

   DNA methylation GrimAge strongly predicts lifespan and healthspan

   Aging·21 Jan 2019

More on Type 2 diabetes