1 paper3 findings
Depressive symptoms
mediatesin humans1
Depressive symptoms mediate accelerated phenotypic aging in humans (20.1% of total effect, P < 0.001).
“Mediation analyses revealed that both DII and depressive symptoms significantly mediated this association, accounting for 11.3 % and 20.1 % of the total effect, respectively (both P < 0.001).”
Humansmediating social disadvantage and accelerated phenotypic agingn = 5,747
Journal of affective disorders30 Jul 2025
Dietary inflammatory index
mediatesin humans1
Dietary inflammatory index mediates accelerated phenotypic aging in humans (11.3% of total effect, P < 0.001).
“Mediation analyses revealed that both DII and depressive symptoms significantly mediated this association, accounting for 11.3 % and 20.1 % of the total effect, respectively (both P < 0.001).”
Humansmediating social disadvantage and accelerated phenotypic agingn = 5,747
Journal of affective disorders30 Jul 2025
Social disadvantage
upin humans1OR 1.41
Social disadvantage is associated with accelerated phenotypic aging in humans (OR 1.41, 95% CI 1.08-1.83, P = 0.013).
“social disadvantage was significantly associated with a 41 % increased risk of accelerated phenotypic aging (OR = 1.41, 95 % CI: 1.08-1.83, P = 0.013).”
Humansn = 5,747
Journal of affective disorders30 Jul 2025
The sweet-tooth group had a 79% higher dementia risk than the group labelled health-aligned in a prospective cohort study.The sweet-tooth group had a 79% higher dementia risk than the group labelled health-aligned in a prospective cohort study.