SIRT1-C152
SIRT1-C152 has been studied in 1 paper since 2016: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Jul 29, 2016: “SIRT1-mediated ERβ suppression in the endothelium contributes to vascular aging”.
1 paper studies it5 findingsUpdated
None of its findings points the other way.
- 1 lab in 1 country
- Funder: National Natural Science Foundation of China
- Animals1
What did studies of SIRT1-C152 find?
5Studies of SIRT1-C152 measured 5 outcomes; the most studied are vascular damage (1 study), mitochondrial function (1) and DNA damage (1).
Vascular damage
downin mice1
1 study
Vascular damage
downin mice1
SIRT1-C152 decreases vascular damage in mice.
“the endothelium-specific delivery of ERβ or SIRT1-C152(D) on the vascular wall reduced the circulating lipids with ameliorated vascular damage”
Animalshigh-fat dietSIRT1-C152(D)vascular wall
SIRT1-mediated ERβ suppression in the endothelium contributes to vascular aging
Aging cell
Mitochondrial function
upin mice1
1 study
Mitochondrial function
upin mice1
SIRT1-C152 improves mitochondrial function in mice.
“A single-mutant SIRT1-C152(D) restored the reduced ERβ expression in the endothelium with minimized reactive oxygen species generation and DNA damage and increased mitochondrial function”
AnimalsSIRT1-C152(D)endothelium
SIRT1-mediated ERβ suppression in the endothelium contributes to vascular aging
Aging cell
DNA damage
downin mice1
1 study
DNA damage
downin mice1
SIRT1-C152 decreases DNA damage in mice.
“A single-mutant SIRT1-C152(D) restored the reduced ERβ expression in the endothelium with minimized reactive oxygen species generation and DNA damage”
AnimalsSIRT1-C152(D)endothelium
SIRT1-mediated ERβ suppression in the endothelium contributes to vascular aging
Aging cell
Reactive oxygen species generation
downin mice1
1 study
Reactive oxygen species generation
downin mice1
SIRT1-C152 decreases reactive oxygen species generation in mice.
“A single-mutant SIRT1-C152(D) restored the reduced ERβ expression in the endothelium with minimized reactive oxygen species generation”
AnimalsSIRT1-C152(D)endothelium
SIRT1-mediated ERβ suppression in the endothelium contributes to vascular aging
Aging cell
ESR2 expression
upin mice1
1 study
ESR2 expression
upin mice1
SIRT1-C152 increases ESR2 expression in mice.
“A single-mutant SIRT1-C152(D) restored the reduced ERβ expression in the endothelium”
AnimalsSIRT1-C152(D)endothelium
SIRT1-mediated ERβ suppression in the endothelium contributes to vascular aging
Aging cell