Severe acute respiratory syndrome coronavirus 2
5 papers study it9 findings
- 4 independent labs in 2 countries
- Funders: National Institutes of Health and others
- Humans2
- Cells2
Outcomes
8Cellular senescence
upin humans1upin reviews1
2 studies
Cellular senescence
upin humans1upin reviews1
Severe acute respiratory syndrome coronavirus 2 induces cellular senescence in humans.
“human stem-cell-derived dopaminergic neurons are susceptible to SARS-CoV-2, triggering inflammation and senescence.”
Reviewstem-cell-derived dopaminergic neuronsbrain
Unraveling the brain's response to COVID-19: How SARS-CoV-2 afflicts dopaminergic neurons
Cell stem cellFeb 1, 2024
Severe acute respiratory syndrome coronavirus 2 induces cellular senescence.
“SARS-CoV-2, like other viruses, can induce senescence and exacerbates the senescence-associated secretory phenotype (SASP)”
Reviewfollowing infection
COVID-19 and cellular senescence
Nature reviews. ImmunologyOct 5, 2022
efferocytosis of neutrophils
downin mice1
1 study
efferocytosis of neutrophils
downin mice1
Severe acute respiratory syndrome coronavirus 2 decreases efferocytosis of neutrophils in mice.
“efferocytosis of neutrophils, whether undergoing apoptosis or NETosis, was compromised after SARS-CoV-2 infection.”
Animalsafter SARS-CoV-2 infectionlung
Compromised efferocytosis during aging is related to COVID-19 severity in mice
Virologica SinicaMay 24, 2025
Respiratory tract hemorrhage
upin mice1
1 study
Respiratory tract hemorrhage
upin mice1
Severe acute respiratory syndrome coronavirus 2 induces respiratory tract hemorrhage in mice.
“Viral infection in aged mice results in severe respiratory tract hemorrhage, likely contributing a higher mortality rate.”
Animalsfollowing SARS-CoV-2 challengerespiratory tract
Premature aging effects on COVID-19 pathogenesis: new insights from mouse models
Scientific reportsAug 24, 2024
Viral replication
upin mice1
1 study
Viral replication
upin mice1
Severe acute respiratory syndrome coronavirus 2 increases viral replication in mice.
“SARS-CoV-2 infection resulted in slightly higher morbidity, mortality, and viral replication in the lungs of old mice”
AnimalsSARS-CoV-2 infectionlung
Age associated susceptibility to SARS-CoV-2 infection in the K18-hACE2 transgenic mouse model
GeroScienceFeb 22, 2024
Mortality
upin mice1
1 study
Mortality
upin mice1
Severe acute respiratory syndrome coronavirus 2 increases mortality in mice.
“SARS-CoV-2 infection resulted in slightly higher morbidity, mortality, and viral replication in the lungs of old mice”
AnimalsSARS-CoV-2 infectionlung
Age associated susceptibility to SARS-CoV-2 infection in the K18-hACE2 transgenic mouse model
GeroScienceFeb 22, 2024
Inflammation
upin humans1
1 study
Inflammation
upin humans1
Severe acute respiratory syndrome coronavirus 2 induces inflammation in humans.
“human stem-cell-derived dopaminergic neurons are susceptible to SARS-CoV-2, triggering inflammation and senescence.”
Reviewstem-cell-derived dopaminergic neuronsbrain
Unraveling the brain's response to COVID-19: How SARS-CoV-2 afflicts dopaminergic neurons
Cell stem cellFeb 1, 2024
TP53
upin human cells1
1 study
TP53
upin human cells1
Severe acute respiratory syndrome coronavirus 2 increases TP53 in human cells.
“SARS-CoV-2 infection induces TP53 stabilization on chromatin, which contributes to its host cytopathic effect.”
Cellsupon infection
Cell reportsNov 21, 2023
Senescence-associated secretory phenotype (SASP)
upin reviews1
1 study
Senescence-associated secretory phenotype (SASP)
upin reviews1
Severe acute respiratory syndrome coronavirus 2 increases senescence-associated secretory phenotype (SASP).
“SARS-CoV-2, like other viruses, can induce senescence and exacerbates the senescence-associated secretory phenotype (SASP)”
Reviewfollowing infection
COVID-19 and cellular senescence
Nature reviews. ImmunologyOct 5, 2022