Cell Stem Cell · Feb 1, 2024

Unraveling the brain's response to COVID-19: How SARS-CoV-2 afflicts dopaminergic neurons

By Eidhof I, Twohig D, Falk A

COVID-19 patients often display dysfunctions of the nervous system, indicating an effect of SARS-CoV-2 on neural cells. Yang et al. now show that human stem-cell-derived dopaminergic neurons are susceptible to SARS-CoV-2, triggering inflammation and senescence. The study further identifies three FDA-approved drugs capable of reversing these cellular phenotypes.

doi.org/10.1016/j.stem.2024.01.002 Open access PubMed 38306990 Mechanisms