Saponins
Outcomes
1Osteoporosis
downin reviews1
1 study
Osteoporosis
downin reviews1
Saponins protect against osteoporosis.
“Saponins regulate bone remodeling bidirectionally through pathways such as PI3K/Akt/mTOR, bone morphogenetic protein 2 (BMP-2)/runt-related transcription factor 2 (Runx2), and RANKL/osteoprotegerin (OPG).”
Reviewvia multi-pathway signaling
Frontiers in nutrition12 Jan 2026
Latest
14 in 12 monthsbioRxiv
A Practical Assay for Assessing Mean Red Blood Cell Age Using the Protein 4.1a/4.1b Ratio
Preprint: cross-sectional study of 114 peopleBiomarkers
Journal of Ginseng Research
Total saponins from Panax ginseng delay aging and cellular senescence via PI3K-AKT pathway in a rapid dual-system screening model of aging
Experiments in human cellsInterventions
Journal of Ginseng Research
Direct targeting of ORAI1 by ginsenoside Rg3 modulates calcium signaling and senescence-associated AMPK-NRF2 activation
Experiments in human cellsInterventions
Journal of Controlled Release
Nanovaccines co-delivering antigen and dual TLR agonists potentiate aged immunity by orchestrating TCR repertoire
Experiments in miceBlood and immune system
Experimental Gerontology
Dioscin extends lifespan and ameliorates aging associated phenotypes in association with the endoplasmic reticulum unfolded protein response
Experiments in wormsInterventions
Food & Nutrition Research
SheVari4®, a proprietary root extract from Asparagus racemosus, ameliorates menopausal health: insights from a randomized, double-blind, placebo controlled clinical trial
Randomised trial in 60 peopleInterventions
Journal of Ethnopharmacology
Ginsenoside Rg2 delays brain aging via inhibiting α-synuclein expression and promoting FoxO-Mediated neurogenesis in mice
Experiments in miceInterventions
Fitoterapia
Anti-aging effects of rare prosaikogenin F from microbial biotransformation of saikosaponin A
Experiments in wormsInterventions