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Rapamycin-loaded mesoporous prussian blue nanoparticles modified with MMP9-targeted peptides

Rapamycin-loaded mesoporous prussian blue nanoparticles modified with MMP9-targeted peptides has been studied in 1 paper since 2024: none in people yet, 1 in animals. The research so far is in animals. The newest paper, May 8, 2024: “Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles”.

Intervention

1 paper studies it3 findingsUpdated

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 2 countries
  • Funders: Basic and Applied Basic Research Foundation of Guangdong Province and 2 more
  • Animals1

What did studies of Rapamycin-loaded mesoporous prussian blue nanoparticles modified with MMP9-targeted peptides find?

3

Studies of Rapamycin-loaded mesoporous prussian blue nanoparticles modified with MMP9-targeted peptides measured 3 outcomes; the most studied are cartilage degradation (1 study), mitophagy (1) and pyroptosis (1).

Cartilage degradation

downin mice1

1 study

  1. Rapamycin-loaded mesoporous prussian blue nanoparticles modified with MMP9-targeted peptides decrease cartilage degradation in mice.

    “After the as-prepared NPs were intra-articularly injected into the CIOA mouse model, they efficiently attenuated synovial macrophage pyroptosis and cartilage degradation.”

    AnimalsCIOA mouse modelcartilage

    Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles

    Acta biomaterialia

Mitophagy

upin mouse cells1

1 study

  1. Rapamycin-loaded mesoporous prussian blue nanoparticles modified with MMP9-targeted peptides activate mitophagy in mouse cells.

    “Moreover, the NPs promoted macrophage mitophagy to restore mitochondrial stability, alleviate pyroptosis-related inflammatory responses, and decrease senescent synoviocytes.”

    Cellsin synovial macrophages

    Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles

    Acta biomaterialia

More on Mitophagy

Pyroptosis

downin mouse cells1

1 study

  1. Rapamycin-loaded mesoporous prussian blue nanoparticles modified with MMP9-targeted peptides inhibit pyroptosis in mouse cells.

    “The inherent enzyme-like activity and RAPA released from RAPA@MPB-MMP9 NPs synergistically impeded the pyroptosis of macrophages”

    Cellsin synovial macrophages

    Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles

    Acta biomaterialia

More on Pyroptosis

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