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PX-866

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Deutsche Forschungsgemeinschaft
  • Cells1

Outcomes

1

Apoptosis

upin human cells1

1 study

  1. PX-866 induces apoptosis in human cells.

    “PX-866 potently induced apoptotic cell death in senescent HCT116, MCF-7 mammary carcinoma, and A549 lung carcinoma cells”

    Cellsin senescent HCT116, MCF-7, and A549 cells

    Combined inhibition of class 1-PI3K-alpha and delta isoforms causes senolysis by inducing p21WAF1/CIP1 proteasomal degradation in senescent cells

    Cell death & diseaseMay 29, 2024

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