Alpelisib

1. Alpelisib increases blood glucose in mice.

   “reductions in bone mass and mild hyperglycemia, were also evident”

   Animals

   Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice

   Nature aging·Jan 23, 2023

2. Alpelisib increases blood glucose in mice.

   “Mice consuming BYL-719 had higher blood glucose and insulin, and tended towards decreased body weight.”

   Animals0.3 g/kg diet6 weeks

   Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function

   Bioscience reports·Oct 30, 2020

More on Blood glucose

1. Alpelisib decreases bone mass in mice.

   “reductions in bone mass and mild hyperglycemia, were also evident”

   Animals

   Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice

   Nature aging·Jan 23, 2023

1. Alpelisib improves balance in mice.

   “long-term PI3Ki treatment was well tolerated and led to greater strength and balance”

   Animals

   Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice

   Nature aging·Jan 23, 2023

1. Alpelisib improves strength in mice.

   “long-term PI3Ki treatment was well tolerated and led to greater strength and balance”

   Animals

   Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice

   Nature aging·Jan 23, 2023

1. Alpelisib extends lifespan in mice.

   “dietary supplementation with the PI3Ki alpelisib from middle age extends the median and maximal lifespan of mice”

   Animals

   Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice

   Nature aging·Jan 23, 2023

1. Alpelisib has no effect on muscle function in mice.

   “consuming BYL719 did not affect food intake, body mass, muscle function (rotarod and hang time performance) or cognitive behaviors”

   Animalsdiet0.3 g/kg6 weeks

   Efficacy of Providing the PI3K p110α Inhibitor BYL719 (Alpelisib) to Middle-Aged Mice in Their Diet

   Biomolecules·Jan 25, 2021

1. Alpelisib impairs glucose tolerance in mice.

   “mice still showed impaired glucose tolerance and insulin sensitivity following 6 weeks of access to a diet containing 0.3 g/kg BYL719”

   Animalsdiet0.3 g/kg6 weeks

   Efficacy of Providing the PI3K p110α Inhibitor BYL719 (Alpelisib) to Middle-Aged Mice in Their Diet

   Biomolecules·Jan 25, 2021

1. Alpelisib inhibits insulin/IGF-1 signalling in mice.

   “Consuming BYL719 resulted in decreased insulin signaling in liver and muscle within 72 h”

   Animalsdietliver and muscle0.3 g/kg72 h

   Efficacy of Providing the PI3K p110α Inhibitor BYL719 (Alpelisib) to Middle-Aged Mice in Their Diet

   Biomolecules·Jan 25, 2021

More on Insulin/IGF-1 signalling

1. Alpelisib decreases hydrogen peroxide in mice.

   “This was associated with an increase in hepatic GSH content and catalase protein expression, and lower H2O2 levels.”

   Animalsliver0.3 g/kg diet6 weeksmales

   Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function

   Bioscience reports·Oct 30, 2020

More on Hydrogen peroxide

1. Alpelisib increases glutathione in mice.

   “This was associated with an increase in hepatic GSH content and catalase protein expression, and lower H2O2 levels.”

   Animalsliver0.3 g/kg diet6 weeksmales

   Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function

   Bioscience reports·Oct 30, 2020

More on Glutathione