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Alpelisib + idelalisib

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Deutsche Forschungsgemeinschaft
  • Cells1

Outcomes

1

Cellular senescence

downin human cells1

1 study

  1. Alpelisib + idelalisib decreases cellular senescence in human cells.

    “simultaneous inhibition of both PI3K class I alpha (with BYL-719 (Alpelisib, Piqray®)) and delta (with CAL-101 (Idelalisib, Zydelig®)) isoforms was sufficient to induce senolysis”

    Cellsin DNA damage-induced senescent tumor cells

    Combined inhibition of class 1-PI3K-alpha and delta isoforms causes senolysis by inducing p21WAF1/CIP1 proteasomal degradation in senescent cells

    Cell death & diseaseMay 29, 2024

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