Polystyrene microplastics

1. Polystyrene microplastics induce ferroptosis in worms.

   “Concurrently, PS-45 induced ferroptosis, as evidenced by increased Fe2+ and malondialdehyde levels, glutathione depletion, and suppression of ftn-1”

   Model organisms45-day photoaged

   Photoaged Polystyrene Microplastics Accelerate Aging in Caenorhabditis elegans via Ferroptosis-Linked Insulin Signaling Pathway

   Environmental science & technology·30 Jan 2026

More on Ferroptosis

1. Polystyrene microplastics inhibit daf-16 nuclear translocation in worms.

   “Mechanistically, PS-45 inhibited DAF-16 nuclear translocation and dysregulated insulin/IGF-1 signaling genes (daf-2, age-1, pdk-1, akt-1, and daf-16).”

   Model organisms45-day photoaged

   Photoaged Polystyrene Microplastics Accelerate Aging in Caenorhabditis elegans via Ferroptosis-Linked Insulin Signaling Pathway

   Environmental science & technology·30 Jan 2026

1. Polystyrene microplastics increase lipofuscin accumulation in worms.

   “Exposure to 100 μg/L PS-0 or PS-45 significantly shortened lifespan, impaired physiological behaviors, and increased lipofuscin accumulation”

   Model organismsvirgin or 45-day photoaged100 μg/L

   Photoaged Polystyrene Microplastics Accelerate Aging in Caenorhabditis elegans via Ferroptosis-Linked Insulin Signaling Pathway

   Environmental science & technology·30 Jan 2026

More on Lipofuscin accumulation

1. Polystyrene microplastics impair physiological behaviors in worms.

   “Exposure to 100 μg/L PS-0 or PS-45 significantly shortened lifespan, impaired physiological behaviors, and increased lipofuscin accumulation”

   Model organismsvirgin or 45-day photoaged100 μg/L

   Photoaged Polystyrene Microplastics Accelerate Aging in Caenorhabditis elegans via Ferroptosis-Linked Insulin Signaling Pathway

   Environmental science & technology·30 Jan 2026

1. Polystyrene microplastics shorten lifespan in worms.

   “Exposure to 100 μg/L PS-0 or PS-45 significantly shortened lifespan, impaired physiological behaviors, and increased lipofuscin accumulation”

   Model organismsvirgin or 45-day photoaged100 μg/L

   Photoaged Polystyrene Microplastics Accelerate Aging in Caenorhabditis elegans via Ferroptosis-Linked Insulin Signaling Pathway

   Environmental science & technology·30 Jan 2026

1. Polystyrene microplastics induce apoptosis in mice.

   “MPs exposure or HFD feeding (and aging) significantly exacerbated the pathological changes developed in colon tissues of mice relative to those of control mice, including gut permeability, oxidative stress, pro-inflammatory response and apoptosis.”

   Animalsduring obesity or agingcolon~25 μg/(kg·day)14 weeks

   Polystyrene microplastics exposure increases the disruption of intestinal barrier integrity and gut microbiota homeostasis during obesity and aging

   Journal of environmental sciences (China)·20 May 2025

More on Apoptosis

1. Polystyrene microplastics increase oxidative stress and ROS signalling in mice.

   “MPs exposure or HFD feeding (and aging) significantly exacerbated the pathological changes developed in colon tissues of mice relative to those of control mice, including gut permeability, oxidative stress, pro-inflammatory response and apoptosis.”

   Animalsduring obesity or agingcolon~25 μg/(kg·day)14 weeks

   Polystyrene microplastics exposure increases the disruption of intestinal barrier integrity and gut microbiota homeostasis during obesity and aging

   Journal of environmental sciences (China)·20 May 2025

More on Oxidative stress and ROS signalling

1. Polystyrene microplastics increase gut permeability in mice.

   “MPs exposure or HFD feeding (and aging) significantly exacerbated the pathological changes developed in colon tissues of mice relative to those of control mice, including gut permeability, oxidative stress, pro-inflammatory response and apoptosis.”

   Animalsduring obesity or agingcolon~25 μg/(kg·day)14 weeks

   Polystyrene microplastics exposure increases the disruption of intestinal barrier integrity and gut microbiota homeostasis during obesity and aging

   Journal of environmental sciences (China)·20 May 2025

More on Gut permeability