Plant sterols

1. Plant sterols have no effect on LDL cholesterol in humans (Change from baseline: +0.1 mg/dL (95% CI -7.1, 7.3) with plant sterols versus +3.9 mg/dL (-7.6, 15.4) with placebo; p = 0.632).

   “LDL-cholesterol did not differ between PS and placebo (p = 0.632)”

   Human trialOverweight or class I–III obesity and mild hypercholesterolemia; compared with placebofood supplement2 g/day8 weeks per phasen = 23

   Dietary supplementation with plant sterols for obesity management and related metabolic disorders: A randomized, double-blind, placebo-controlled crossover clinical trial

   The American journal of clinical nutrition·16 Oct 2026

2. Plant sterols decrease LDL cholesterol in rats.

   “effectively prevented the diet-induced increases in total and LDL cholesterols and 24-h systolic and mean blood pressures”

   Animalsin obese Zucker rats fed an atherogenic diet

   Supplementation of plant sterols and minerals benefits obese Zucker rats fed an atherogenic diet

   The Journal of nutrition·1 Feb 2002

More on LDL cholesterol

1. Plant sterols have no effect on sarcopenia parameters in humans.

   “no between-treatment difference in body composition, sarcopenia or lifestyle parameters remained significant after correction for multiple testing.”

   Human trialCompared with placebo; exploratory outcome, corrected for multiple testingfood supplement2 g/day8 weeks per phasen = 23

   Dietary supplementation with plant sterols for obesity management and related metabolic disorders: A randomized, double-blind, placebo-controlled crossover clinical trial

   The American journal of clinical nutrition·16 Oct 2026

1. Plant sterols have no effect on body composition in humans.

   “no between-treatment difference in body composition, sarcopenia or lifestyle parameters remained significant after correction for multiple testing.”

   Human trialCompared with placebo; exploratory outcome, corrected for multiple testingfood supplement2 g/day8 weeks per phasen = 23

   Dietary supplementation with plant sterols for obesity management and related metabolic disorders: A randomized, double-blind, placebo-controlled crossover clinical trial

   The American journal of clinical nutrition·16 Oct 2026

1. Plant sterols protect against vascular and renal damage in rats.

   “Plant sterols and the minerals also protected against vascular and renal damage”

   Animalsin obese Zucker rats fed an atherogenic diet

   Supplementation of plant sterols and minerals benefits obese Zucker rats fed an atherogenic diet

   The Journal of nutrition·1 Feb 2002

1. Plant sterols improve endothelial function in rats.

   “and markedly improved endothelial function”

   Animalsin obese Zucker rats fed an atherogenic diet

   Supplementation of plant sterols and minerals benefits obese Zucker rats fed an atherogenic diet

   The Journal of nutrition·1 Feb 2002

More on Endothelial function

1. Plant sterols decrease blood pressure in rats.

   “effectively prevented the diet-induced increases in total and LDL cholesterols and 24-h systolic and mean blood pressures”

   Animalsin obese Zucker rats fed an atherogenic diet

   Supplementation of plant sterols and minerals benefits obese Zucker rats fed an atherogenic diet

   The Journal of nutrition·1 Feb 2002

More on Blood pressure

1. Plant sterols extend lifespan in rats (+60%).

   “Plant sterols and the minerals also protected against vascular and renal damage and extended the life span of the obese Zucker rats by 60% compared with the rats fed the atherogenic diet.”

   Animalsin obese Zucker rats fed an atherogenic diet

   Supplementation of plant sterols and minerals benefits obese Zucker rats fed an atherogenic diet

   The Journal of nutrition·1 Feb 2002