Phytic acid
Phytic acid has been studied in 6 papers since 2016: 2 observational studies in people, 1 in animals, 3 reviews; 1 in the past year. The newest paper, Nov 25, 2025: “A prospective association between dietary phytate intake and risk of fracture in middle-aged and older adults: a 12-Year prospective cohort study”.
See all 8 papers on phytic acid
At a glance
The findings reach people, from one lab or study. 3 independent labs in 3 countries.
“participants in the highest tertile of dietary phytate intake (> 2598 mg/d) had a significantly lower risk of fracture (HR = 0.40, 95% CI = 0.21-0.775, P = 0.006)”
None of its findings points the other way.
- 3 independent labs in 3 countries
- Humans2
- Animals1
What did studies of phytic acid find?
6Studies of phytic acid measured 6 outcomes; the most studied are oxidative stress and ROS signaling (1 study), osteogenesis (1) and cellular senescence (1).
Oxidative stress and ROS signaling
downin reviews1
1 study
Oxidative stress and ROS signaling
downin reviews1
Phytic acid protects against oxidative stress and ROS signaling.
“phytates protect against oxidative damage”
Review
Ageing research reviews
Osteogenesis
upin humans1
1 study
Osteogenesis
upin humans1
Phytic acid increases osteogenesis in humans.
“increased osteogenesis in animal experiments”
Animals
Chemico-biological interactions
Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
Phytic acid prevents cellular senescence in human cells (high-glucose-induced).
“PA also prevented high-glucose-induced senescence of BMSCs”
Cellshigh-glucose-induced
Chemico-biological interactions
Osteogenic differentiation
upin human cells1
1 study
Osteogenic differentiation
upin human cells1
Phytic acid increases osteogenic differentiation in human cells under high-glucose conditions.
“osteogenic differentiation in BMSCs cultivated in high-glucose conditions is enhanced by PA”
Cellsunder high-glucose conditions
Chemico-biological interactions
Cardiovascular calcification
downin rats1
1 study
Cardiovascular calcification
downin rats1
Phytic acid prevents cardiovascular calcification in rats (induced by vitamin D).
“Intravenous phytate prevents aggressive CVC induced by vitamin D in rats”
Reviewinduced by vitamin D
Medical hypotheses
Vascular calcification
downin rats1
1 study
Vascular calcification
downin rats1
Phytic acid prevents vascular calcification in rats.
“Dietary phytate prevents the calcification of ageing in rats”
Reviewdietary
Medical hypotheses
What is phytic acid linked with?
3Studies link phytic acid with 3 measures, most often bone fracture (1 study), cognitive function (1) and cardiovascular calcification (1).
Bone fracture
downin humans1HR 0.4
1 study
Bone fracture
downin humans1HR 0.4
Phytic acid is linked with a lower risk of bone fracture in humans (adjusted for confounders) (HR = 0.40, 95% CI = 0.21-0.775, P = 0.006).
“participants in the highest tertile of dietary phytate intake (> 2598 mg/d) had a significantly lower risk of fracture (HR = 0.40, 95% CI = 0.21-0.775, P = 0.006)”
Humansadjusted for confounders> 2598 mg/d vs < 1770 mg/d11.5 yearsn = 1,917
Aging clinical and experimental research
Cognitive function
upin humans1
1 study
Cognitive function
upin humans1
Phytic acid is associated with cognitive function in humans (β = 1.90 (95% CI 0.73-3.07), p = 0.015).
“phytate intake was positively associated with cognitive function (β (95% CI) = 1.90 (0.73-3.07); p = 0.015)”
Humans
Antioxidants (Basel, Switzerland)
Cardiovascular calcification
downin humans1
1 study
Cardiovascular calcification
downin humans1
Phytic acid is associated with cardiovascular calcification in the elderly.
“epidemiological data suggest that phytate rich diets are associated with a lower incidence of CVC in the elderly”
Reviewin the elderlydietary
Medical hypotheses