Phloretin

4 papers study it6 more mention it3 findings

PubChem ChEBI MeSH

1 lab in 1 country

Funders: Fundamental Research Funds for the Central Universities and 1 more

Model organisms1
In silico2

Outcomes

3

ATP

downin worms1

1 study

Phloretin decreases ATP in worms.
“Meanwhile, with the inhibition of mitochondrial complex I, ATP was instantly decreased.”
Model organisms
Phloretin prolongs lifespan of Caenorhabditis elegans via inhibition of NDUFS1 and NDUFS6 at mitochondrial complex Ⅰ
Free radical biology & medicineMay 3, 2024

Oxidative stress and ROS signaling

upin worms1

1 study

Phloretin induces oxidative stress and ROS signaling in worms.
“The lifespan-extending effects of phloretin were mediated by ROS via mitochondrial complex I inhibition.”
Model organisms
Phloretin prolongs lifespan of Caenorhabditis elegans via inhibition of NDUFS1 and NDUFS6 at mitochondrial complex Ⅰ
Free radical biology & medicineMay 3, 2024

More on Oxidative stress and ROS signaling

Lifespan

upin worms1

1 study

Phloretin extends lifespan in worms.
“administration of phloretin of apple polyphenols extended lifespan of Caenorhabditis elegans and promoted fitness.”
Model organismsadministration of phloretin
Phloretin prolongs lifespan of Caenorhabditis elegans via inhibition of NDUFS1 and NDUFS6 at mitochondrial complex Ⅰ
Free radical biology & medicineMay 3, 2024

Latest

International Journal of Molecular SciencesOct 16

Phlorizin Ameliorates Amyloid-β Toxicity and Enhances Fatty Acid β-Oxidation in Caenorhabditis elegans via NHR-49-Dependent Pathway

Experiments in wormsInterventions

AntioxidantsAug 31

A Randomised, Double-Blind, Placebo-Controlled, Cross-Over Clinical Trial to Evaluate the Biological Effects and Safety of a Polyphenol Supplement on Healthy Ageing

Randomized trial in 30 peopleInterventions

Free Radical Biology & MedicineMay 6

Phloretin prolongs lifespan of Caenorhabditis elegans via inhibition of NDUFS1 and NDUFS6 at mitochondrial complex Ⅰ

Experiments in wormsInterventions

Scientific ReportsMar 16

Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Computational studyInterventions

AntioxidantsOct 28

Anti-Oxidant and Anti-Aging Effects of Phlorizin Are Mediated by DAF-16-Induced Stress Response and Autophagy in Caenorhabditis elegans

Experiments in wormsInterventions

Medicinal Chemistry (Shariqah (United Arab Emirates))Oct 25

Natural Products as a Major Source of Candidates for Potential Senolytic Compounds obtained by in silico Screening

Computational studySenolytics

European Journal of PharmacologyMay 6

Exploring the role of senescence inducers and senotherapeutics as targets for anticancer natural products

ReviewInterventions

Oxidative Medicine and Cellular LongevityNov 6

Epigallocatechin Gallate Effectively Affects Senescence and Anti-SASP via SIRT3 in 3T3-L1 Preadipocytes in Comparison with Other Bioactive Substances

Experiments in cellsInterventions

The Journal of Nutritional BiochemistrySep 4

Dietary phlorizin enhances osteoblastogenic bone formation through enhancing β-catenin activity via GSK-3β inhibition in a model of senile osteoporosis

Experiments in animalsInterventions

American Journal of Respiratory Cell and Molecular BiologyDec 21

Glucose Transporter 1-Dependent Glycolysis Is Increased during Aging-Related Lung Fibrosis, and Phloretin Inhibits Lung Fibrosis

Experiments in animalsMechanisms