Semaglutide + peptide yy 3-36
Semaglutide + peptide yy 3-36 has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest paper, Jul 29, 2026: “PYY₃₋₃₆ potentiates semaglutide-mediated mitochondrial modulation in MASLD”.
1 paper studies it3 findingsUpdated
See all 1 papers on semaglutide + peptide yy 3-36
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Deutsche Forschungsgemeinschaft and 1 more
- Animals1
What did studies of semaglutide + peptide yy 3-36 find?
3Studies of semaglutide + peptide yy 3-36 measured 3 outcomes; the most studied are hydrogen peroxide (1 study), oxidative phosphorylation (1) and histological MASLD score (1).
Hydrogen peroxide
downin rats1
1 study
Hydrogen peroxide
downin rats1
Semaglutide + peptide yy 3-36 decreases hydrogen peroxide in obese rats with MASLD.
“Superior effects occurred in the semaglutide + PYY3−36 group with a decline in mitochondrial respiration, decreased mitochondrial H2O2 production and reduced hepatocellular stress”
Animalsin obese rats with MASLDliver8 wkmalesn = 10
PYY₃₋₃₆ potentiates semaglutide-mediated mitochondrial modulation in MASLD
American journal of physiology. Endocrinology and metabolism
Oxidative phosphorylation
downin rats1
1 study
Oxidative phosphorylation
downin rats1
Semaglutide + peptide yy 3-36 inhibits oxidative phosphorylation in obese rats with MASLD.
“Oxidative phosphorylation (OxPhos)-related genes were significantly reduced in Sema + PYY3−36, consistent with mitochondrial respirometry.”
Animalsin obese rats with MASLDliver8 wkmalesn = 10
PYY₃₋₃₆ potentiates semaglutide-mediated mitochondrial modulation in MASLD
American journal of physiology. Endocrinology and metabolism
Histological MASLD score
downin rats1
1 study
Histological MASLD score
downin rats1
Semaglutide + peptide yy 3-36 decreases histological MASLD score in high-fat/fructose diet and l-NAME-induced obese rats.
“Hepatic inflammation and histological MASLD score were significantly mitigated by semaglutide and PYY3−36 with additive effects in the combination group.”
Animalsin high-fat/fructose diet and l-NAME-induced obese ratsliver8 wkmalesn = 10
PYY₃₋₃₆ potentiates semaglutide-mediated mitochondrial modulation in MASLD
American journal of physiology. Endocrinology and metabolism