Ntbuha
1 paper3 findings
- 1 lab in 1 country
- Animals1
Outcomes
3RAB7A
downin human cells1
1 study
RAB7A
downin human cells1
Ntbuha decreases RAB7A in human cells.
“We also observed lower expression of APP and Rab7 in iNs treated with 2 Mm of NtBuHa compared to control iNs.”
Cellsin iPSC-derived neurons harboring familial APP mutation2 mM48 hours
The role of lysosomal depalmitoylation in Alzheimer's Disease in vitro and in vivo models
AAIC 2025 abstract24 Dec 2025
APP
downin human cells1
1 study
APP
downin human cells1
Ntbuha decreases APP in human cells.
“We also observed lower expression of APP and Rab7 in iNs treated with 2 Mm of NtBuHa compared to control iNs.”
Cellsin iPSC-derived neurons harboring familial APP mutation2 mM48 hours
The role of lysosomal depalmitoylation in Alzheimer's Disease in vitro and in vivo models
AAIC 2025 abstract24 Dec 2025
Amyloid-beta 40
downin human cells1
1 study
Amyloid-beta 40
downin human cells1
Ntbuha decreases amyloid-beta 40 in human cells.
“Our preliminary data indicate that 2Mm of NtBuHa significantly reduces Aβ‐40 levels in the media of iNs compared to untreated iNs”
Cellsin iPSC-derived neurons harboring familial APP mutation2 mM48 hours
The role of lysosomal depalmitoylation in Alzheimer's Disease in vitro and in vivo models
AAIC 2025 abstract24 Dec 2025