AAV9-PPT1

AAV9-PPT1 improves lifespan in mice (at least 18 months).

“Multiple injections of AAV9‐PPT1 into the cortex and hippocampus at 3.5 months of age improved the survival of the animals for at least 18 months.”

Animalsin 5xFAD micecortex and hippocampusat least 18 months

The role of lysosomal depalmitoylation in Alzheimer's Disease in vitro and in vivo models

AAIC 2025 abstract·24 Dec 2025