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NOX1 inhibitor

NOX1 inhibitor has been studied in 1 paper since 2021: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Oct 17, 2021: “Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence”.

Intervention

1 paper studies it4 findingsUpdated

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: American Heart Association and 3 more
  • Animals1

What did studies of NOX1 inhibitor find?

4

Studies of NOX1 inhibitor measured 4 outcomes; the most studied are senescence-associated secretory phenotype (SASP) (1 study), vasodilation (1) and angiogenesis (1).

Senescence-associated secretory phenotype (SASP)

downin mice1

1 study

  1. NOX1 inhibitor decreases senescence-associated secretory phenotype (SASP) in mice.

    “while disrupting a NOX1-IL-6 senescence-associated secretory phenotype (SASP) proinflammatory signaling loop”

    Animalsagingvasculature

    Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence

    Proceedings of the National Academy of Sciences of the United States of America

More on Senescence-associated secretory phenotype (SASP)

Vasodilation

upin mice1

1 study

  1. NOX1 inhibitor improves vasodilation in mice.

    “selective NOX1 inhibition rescues age-impaired blood flow and angiogenesis, vasodilation, and the endothelial cell wound response”

    Animalsagingvasculature

    Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence

    Proceedings of the National Academy of Sciences of the United States of America

Angiogenesis

upin mice1

1 study

  1. NOX1 inhibitor increases angiogenesis in mice.

    “NOX1i delivery in vivo completely reversed age-impaired hind-limb blood flow and angiogenesis”

    Animalsage-impaired hind limbhind limb

    Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence

    Proceedings of the National Academy of Sciences of the United States of America

More on Angiogenesis

Blood flow

upin mice1

1 study

  1. NOX1 inhibitor improves blood flow in mice.

    “NOX1i delivery in vivo completely reversed age-impaired hind-limb blood flow and angiogenesis”

    Animalsage-impaired hind limbhind limb

    Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence

    Proceedings of the National Academy of Sciences of the United States of America

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