NETRIN-1
- 2 independent labs in 2 countries
- Funders: National Heart, Lung, and Blood Institute and others
- Humans2
- Animals2
Outcomes
5Regenerative potential
upin mice1
1 study
Regenerative potential
upin mice1
NETRIN-1 improves regenerative potential in mice.
“restore regenerative potential of the aged BM niche and blood stem cells to endure serial chemotherapy regimens.”
Animalsserial chemotherapy regimens
Nature communications
DNA damage
downin mice1
1 study
DNA damage
downin mice1
NETRIN-1 decreases DNA damage in mice.
“Netrin-1 supplementation is sufficient to resolve DNA damage”
Animalsaging-associated decline in niche-derived Netrin-1bone marrow microenvironment
Nature communications
Competitive fitness of aged blood stem cells
upin mice1
1 study
Competitive fitness of aged blood stem cells
upin mice1
NETRIN-1 improves competitive fitness of aged blood stem cells in mice.
“supplementation of aged mice with Netrin-1 rejuvenates aged niche cells and restores competitive fitness of aged blood stem cells to youthful levels.”
Animalssupplementation of aged mice
Nature communications
Cell migration
upin human cells1
1 study
Cell migration
upin human cells1
NETRIN-1 increases cell migration in human cells.
“Finally, we revealed a potent migratory effect of ACM and NTN-1 on Caco-2 cells.”
Cellsin vitro
Cancers
Inflammation
upin human cells1
1 study
Inflammation
upin human cells1
NETRIN-1 induces inflammation in human cells (p < 0.05).
“The treatment of adipocytes with NTN-1 promoted the upregulation (p < 0.05) of pro-inflammatory and chemotactic molecules”
Cellsvisceral adipocytes
Nutrients
Funding
1 grant since 2019National Heart, Lung, and Blood InstituteUS$88.9k