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DCC

Gene

2 papers study it1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Canadian Institutes of Health Research and 2 more
  • Humans1
  • Animals1

Effects

1

Dopaminergic neuron survival

upin mice1

1 study

  1. DCC increases dopaminergic neuron survival in mice.

    “Reduced numbers of mDA neurons were detected in the substantia nigra pars compacta (SNc) of young adult DATcre /DCCfl/fl mice, with further reduction in aged DATcre /DCCfl/fl animals.”

    Animalsshown by conditional knockoutsubstantia nigra pars compacta

    The netrin-1 receptor DCC promotes the survival of a subpopulation of midbrain dopaminergic neurons: Relevance for ageing and Parkinson's disease

    Journal of neurochemistryFeb 5, 2022

Funding

3 grants since 2017

National Heart, Lung, and Blood InstituteUS$3.1m

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