Neighborhood physical disorder

5 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

4 independent labs in 2 countries

Humans5

Outcomes

Multiple chronic conditions burden

no changein humans1

1 study

Neighborhood physical disorder has no effect on multiple chronic conditions burden in humans.
“No significant associations were found for physical disorder, either at baseline or in changes over time.”
HumansBaseline physical disorder and changes over time6 yearsn = 3,389
Neighborhood Social Cohesion, Physical Disorder, and Multiple Chronic Conditions in Older Adults: An Examination of Racial/Ethnic Differences
Journal of aging and health31 Aug 2025

Associations

Cognitive function

upin humans1

1 study

Neighborhood physical disorder is associated with cognitive function in humans (β = .043, p < .001).
“greater physical disorder was linked to better cognitive functioning (β = .043, p < .001)”
Humansfully-adjusted structural equation models
The Role of Neighborhood Stressors on Cognitive Functioning in Urban-Dwelling Brazilian Adults
GSA 2025 abstract31 Dec 2025

Physical activity

downin humans1

1 study

Neighborhood physical disorder is associated with physical activity in humans (B=-1.23, 95%CI=-2.09, -0.38).
“Conversely, any sign of neighborhood physical disorder (B=-1.23, 95%CI=-2.09, -0.38) was associated with reduced physical activity.”
Humansamong people with dementian = 3,073
NEIGHBORHOOD ENVIRONMENT AND PHYSICAL ACTIVITY AMONG PERSONS WITH DEMENTIA
GSA 2024 abstract31 Dec 2024

Self-care limitations

downin humans1

1 study

Neighborhood physical disorder is associated with self-care limitations in humans (Coef.= -0.011, p= 0.021).
“self-care limitations were associated with IC × physical disorder (Coef.= -0.011, p= 0.021)”
Humansinteraction with intrinsic capacityn = 7,494
MODERATING ROLE OF NEIGHBORHOOD CHARACTERISTICS ON INTRINSIC CAPACITY AND FUNCTIONAL LIMITATIONS
GSA 2024 abstract31 Dec 2024