Neighborhood affluence

4 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Humans4

Outcomes

CD4+ central memory T cell percentage

downin humans1

1 study

Neighborhood affluence decreases CD4+ central memory T cell percentage in humans (35.8% vs. 36.8%, p < 0.05).
“lower CD4+ central memory T cells (35.8% vs. 36.8%, p < 0.05) than those in the least affluent neighborhoods”
Humansbloodn = 7,660
Neighborhood Socioeconomic Environment Associated With Aging-Related Immune Phenotypes
GSA 2025 abstract31 Dec 2025

More on CD4+ central memory T cell percentage

CD4+ naive T cell percentage

upin humans1

1 study

Neighborhood affluence increases CD4+ naive T cell percentage in humans (45.6% vs. 43.1%, p < 0.001).
“Residents of the most affluent neighborhoods had higher CD4+ naïve T cells (45.6% vs. 43.1%, p < 0.001)”
Humansbloodn = 7,660
Neighborhood Socioeconomic Environment Associated With Aging-Related Immune Phenotypes
GSA 2025 abstract31 Dec 2025

Associations

Physical activity

upin humans1

1 study

Neighborhood affluence is associated with physical activity in humans (B=0.45, 95% CI=0.07, 0.84).
“Higher neighborhood socioeconomic affluence (B=0.45, 95% CI=0.07, 0.84) and social cohesion (B=0.70, 95% CI=0.32, 1.09) were associated with higher levels of physical activity.”
Humansamong people with dementian = 3,073
NEIGHBORHOOD ENVIRONMENT AND PHYSICAL ACTIVITY AMONG PERSONS WITH DEMENTIA
GSA 2024 abstract31 Dec 2024