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Muscone

Muscone has been studied in 1 paper since 2025: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Aug 14, 2025: “Muscone suppresses inflammation and senescence of nucleus pulposus via p53 signalling during intervertebral disc degeneration”.

Intervention

1 paper studies it5 findingsUpdated

PubChemChEBI

See all 1

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

What did studies of Muscone find?

5

Studies of Muscone measured 5 outcomes; the most studied are intervertebral disc degeneration (1 study), TP53 (1) and cell proliferation (1).

Intervertebral disc degeneration

downin cells1

1 study

  1. Muscone protects against intervertebral disc degeneration in cells.

    “muscone protects against the degeneration of nucleus pulposus cells by inhibiting p53 signaling and thus may have therapeutic value for IDD.”

    Cellsnucleus pulposus

    Muscone suppresses inflammation and senescence of nucleus pulposus via p53 signalling during intervertebral disc degeneration

    Scientific reports

More on Intervertebral disc degeneration

TP53

downin cells1

1 study

  1. Muscone inhibits TP53 in cells.

    “Further validation confirmed both in vivo and in vitro that muscone could regulate ECM-related genes, cell apoptosis, cell senescence and the SASP by inhibiting p53.”

    Cellsnucleus pulposus

    Muscone suppresses inflammation and senescence of nucleus pulposus via p53 signalling during intervertebral disc degeneration

    Scientific reports

More on TP53

Cell proliferation

upin cells1

1 study

  1. Muscone increases cell proliferation in cells during inflammation.

    “muscone can increase the expression of ECM anabolism-related genes and the proliferation of NP cells during inflammation.”

    Cellsduring inflammationnucleus pulposus

    Muscone suppresses inflammation and senescence of nucleus pulposus via p53 signalling during intervertebral disc degeneration

    Scientific reports

Apoptosis

downin cells1

1 study

  1. Muscone decreases apoptosis in NP cells.

    “Muscone exerts protective effects by inhibiting the expression of ECM catabolism-related genes, cell apoptosis, the cell senescence and senescence-associated secretory phenotype (SASP) in NP cells”

    Cellsin NP cellsnucleus pulposus

    Muscone suppresses inflammation and senescence of nucleus pulposus via p53 signalling during intervertebral disc degeneration

    Scientific reports

More on Apoptosis

Cellular senescence

downin cells1

1 study

  1. Muscone decreases cellular senescence in NP cells.

    “Muscone exerts protective effects by inhibiting the expression of ECM catabolism-related genes, cell apoptosis, the cell senescence and senescence-associated secretory phenotype (SASP) in NP cells”

    Cellsin NP cellsnucleus pulposus

    Muscone suppresses inflammation and senescence of nucleus pulposus via p53 signalling during intervertebral disc degeneration

    Scientific reports

More on Cellular senescence

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