Morphine

Intervention Approved 1984

1 paper1 finding

PubChem 5288826 ChEBI 17303 MeSH D009020

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country
0 on aging of 239 trials, 70 with no results posted

Funders: National Heart, Lung, and Blood Institute and 1 more

Animals1

Outcomes

Oxidative phosphorylation

downin rats1

1 study

Morphine decreases oxidative phosphorylation in rats.
“Surgery and morphine treatment also produced persistent hippocampal mitochondrial dysfunction, characterized by impaired oxidative phosphorylation”
Animalsin aged ratshippocampus
Disruption of hippocampal mitochondrial function underlies opioid-induced postoperative cognitive dysfunction in aged rats
Brain, behavior, and immunity3 Aug 2026

Trials

0 on aging of 239

Approved

FDA Duramorph PF, Infumorph
18 Sep 1984Chronic Pain
FDA MS Contin
29 May 1987MS CONTIN is indicated for the management of severe and persistent pain that requires an opioid analgesic and that cannot be adequately…
FDA Morphine Sulfate (Autoinjector)
12 Jul 1990Discontinued
FDA Oramorph SR
15 Aug 1991Discontinued
FDA Morphine Sulfate
30 Oct 1992Discontinued
FDA Morphine Sulfate
30 Oct 1992Discontinued

All 17

FDA Kadian
3 Jul 1996Discontinued
FDA Morphine Sulfate
3 Jul 1996Discontinued
FDA Avinza
20 Mar 2002Discontinued
FDA Depodur
18 May 2004Discontinued
FDA Morphine Sulfate
17 Mar 2008Acute Pain, Chronic Pain
FDA Morphine Sulfate
17 Mar 2008Acute Pain, Chronic Pain
FDA Morphine Sulfate
23 Jun 2011Discontinued
FDA Morphine Sulfate
14 Nov 2011Morphine Sulfate Injection is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative…
FDA Morphine Sulfate
30 Oct 2013Morphine Sulfate Injection is an opioid agonist indicated for the management of pain severe enough to require an opioid analgesic and for…
FDA Morphabond ER
2 Oct 2015Discontinued
FDA Arymo ER
9 Jan 2017Discontinued

Repurposing

Cardiovascular disease
Phase 4Completed1 trial
Obesity
Phase 4Status unknown1 trial
Coronary artery disease
Phase 4Results posted1 trial
Insulin resistance
Phase 4Results posted1 trial
Chronic disease
Phase 4Terminated1 trial
Hip fracture
Phase 4Terminated1 trial

40 of 71

Chronic obstructive pulmonary disease
Phase 3Completed4 trials
Osteoarthritis
Phase 4Results posted8 trials
Obstructive sleep apnea
Phase 4Results posted3 trials
Knee osteoarthritis
Phase 4Results posted4 trials
Sepsis
Phase 4Status unknown1 trial
Liver disease
Phase 4Status unknown1 trial
Idiopathic pulmonary fibrosis
Phase 3Results posted2 trials
Neoplasm
Phase 3Completed5 trials
Multiple myeloma
Phase 3Completed2 trials
Lung disease
Phase 4Completed1 trial
Myelodysplastic syndrome
Phase 3Completed1 trial
Glucose intolerance
Phase 4Results posted1 trial
Low back pain
Phase 4Completed2 trials
Leukemia
Phase 3Completed1 trial
Pain
Phase 4Results posted43 trials
Femoral fractures
Phase 4Results posted2 trials
Lymphoma
Phase 3Completed2 trials
Hypotension
Phase 4Completed1 trial
Constipation
Phase 4Status unknown1 trial
Hematologic neoplasms
Phase 3Active, not recruiting2 trials
Substance-related disorders
Phase 4Terminated2 trials
Chronic wound
Phase 3Terminated1 trial
Herpes zoster
Phase 3Completed1 trial
Nephrolithiasis
Phase 3Recruiting1 trial
Chronic low back pain
Phase 4Results posted1 trial
Back pain
Phase 3Results posted2 trials
Ileus
Phase 4Status unknown2 trials
ST-elevation myocardial infarction
Phase 4Status unknown2 trials
Hypoxia
Phase 3Terminated1 trial
Postherpetic neuralgia
Phase 3Results posted1 trial
Right ventricular dysfunction
Phase 4Status unknown1 trial
Sleep apnea syndromes
Phase 3Terminated1 trial
Scoliosis
Phase 3Results posted3 trials
Dyspnea
Phase 3Completed2 trials

In trials

Postoperative pain
Phase 4Results posted46 trials
Opioid-Related Disorders
Phase 4Terminated11 trials
Emergencies
Phase 4Results posted5 trials
Renal Colic
Phase 4Completed4 trials
Neuralgia
Phase 4Completed3 trials
Sickle Cell Anemia
Phase 4Results posted3 trials

All 27

Ankle Fractures
Phase 4Results posted2 trials
Head and Neck Neoplasms
Phase 4Results posted2 trials
Postoperative Nausea and Vomiting
Phase 4Completed2 trials
Sedation
Phase 4Completed2 trials
Vaso-Occlusive Crises
Phase 4Results posted2 trials
Myocardial reperfusion injury
Phase 4Completed1 trial
Stomach neoplasm
Phase 4Completed1 trial
Urolithiasis
Phase 4Completed1 trial
Cancer Pain
Phase 3Completed6 trials
Mucositis
Phase 3Terminated3 trials
Pregnant Women
Phase 3Completed3 trials
Kidney neoplasm
Phase 3Recruiting1 trial
Waldenström macroglobulinemia
Phase 3Completed1 trial
Anesthesia
Phase 2/3Results posted2 trials
Neoplasm metastasis
Phase 2Results posted3 trials
Breast neoplasm
Phase 2Terminated2 trials
Heroin Dependence
Phase 2Completed2 trials
Sciatica
Phase 2Completed2 trials
Malignant pleural effusion
Phase 2Status unknown1 trial
Fasting
Phase 1Completed1 trial
Recurrence
Phase 1Results posted1 trial

Stopped

NCT01100437TerminatedChronic pain
See termination reason in detailed description.
NCT01179191TerminatedChronic pain
See termination reason in detailed description.
NCT00270322TerminatedPostoperative pain
We believe regional anesth better for TKR,90% patients got epidural. Last year we started spinal morphine one shot, and found it very promissing.
NCT00681174TerminatedPostoperative pain
Failure to enroll sufficient patients by expected deadline.
NCT02746263TerminatedPostoperative pain
Business decision because enrollment was slower than expected
NCT03846102TerminatedPain
COVID-19 crisis.

All 13

NCT02741076TerminatedOpioid-Related Disorders
Inability to recruit sufficient no. of subjects over an acceptable time period
NCT02173756TerminatedNeoplasm
Numerous premature study discontinuations due to adverse events
NCT03127800TerminatedCentral sleep apnea
Difficulties with recruitment
NCT02028923TerminatedChronic wound
Recruiting patients too low
NCT00678145TerminatedDiabetes mellitus
Protocol was terminated due to enrollment + feasibility issues. Aim 2 not conducted. Aims 1 + 3 were conducted in part. During Aim 3 the IRB requested that the study be transitioned under a new protocol (2018-9208) in order to simplify reporting.
NCT05017246TerminatedLeiomyoma
Low accrual
NCT01882530Terminated
Practice on postoperative pain management changed