Midlife body mass index

1. Midlife body mass index decreases AD-signature region cerebral glucose metabolism in humans (β = − 0.009; 95% CI, − 0.015 to − 0.003; p < .01).

   “Higher midlife BMI correlated significantly with lower AD-CM (β = − 0.009; 95% CI, − 0.015 to − 0.003; p < .01).”

   Humansnon-demented older adultsbrainn = 268

   BMI changes from midlife to late life and their relationship with Alzheimer's disease pathologies

   Alzheimer's research & therapy·23 Jan 2026

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