Decreasing body mass index

1. Decreasing body mass index decreases AD-signature region cerebral glucose metabolism in humans (β = 0.029; 95% CI, 0.003 to 0.055; p = .027).

   “Participants with decreasing BMI patterns from midlife to late life exhibited significantly lower AD-CM compared to those with increasing patterns (β = 0.029; 95% CI, 0.003 to 0.055; p = .027).”

   Humansnon-demented older adults, decreasing vs increasing patternsbrainn = 268

   BMI changes from midlife to late life and their relationship with Alzheimer's disease pathologies

   Alzheimer's research & therapy·23 Jan 2026

More on AD-signature region cerebral glucose metabolism