Tau deposition

1. Sleep disturbance increases tau deposition in humans (corrected p -value < 0.05).

   “overall sleep disturbances and their interaction with AD diagnosis significantly impact tau deposition in key AD‐sensitive brain regions”

   Humansbrain

   The Association between Sleep Disturbances, Imaging Biomarkers and Cognitive Decline along the Trajectory of Alzheimer's Disease

   AAIC 2025 abstract·24 Dec 2025

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1. Phasic locus coeruleus activity is associated with tau deposition in humans.

   “Lower phasic LC activity was associated with greater baseline EC tau deposition (Figure 2A‐B) and faster medial temporal lobe tau accumulation”

   Humansasymptomatic older adultsentorhinal cortex

   Lower resting‐state phasic locus coeruleus activity is associated with cortical tau accumulation and cognitive decline in preclinical Alzheimer's disease

   AAIC 2025 abstract·8 Jan 2026

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1. Basal forebrain functional connectivity predicts tau deposition in humans (d=0.49).

   “Tau‐PET uptake was significantly greater in both the ERC and BF FC network compared to outside the network”

   Humansin unimpaired older adultsbrain

   Basal forebrain and entorhinal cortex functional connectivity predicts regional tau burden in cognitively normal older adults

   AAIC 2025 abstract·7 Jan 2026

1. Entorhinal cortex functional connectivity predicts tau deposition in humans (d=0.85).

   “Tau‐PET uptake was significantly greater in both the ERC and BF FC network compared to outside the network”

   Humansin unimpaired older adultsbrain

   Basal forebrain and entorhinal cortex functional connectivity predicts regional tau burden in cognitively normal older adults

   AAIC 2025 abstract·7 Jan 2026

1. Pulse pressure is associated with tau deposition in humans (standardized β = 0.11, p = 0.020).

   “elevated PP was significantly associated with increased global and inferior temporal tau deposition (standardized β = 0.11, p = 0.020; standardized β = 0.12, p = 0.012).”

   Humanscognitively unimpairedn = 411

   Pulse pressure is associated with Alzheimer's disease pathology and cognitive decline

   AAIC 2025 abstract·25 Dec 2025

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1. Eye movement features are associated with tau deposition in humans (p = 0.05).

   “central(mean) features showed a significant negative association with tau deposition in the temporal lobe ( p = 0.05).”

   Humansinpatient participantstemporal loben = 101

   Artificial intelligence‐based eye‐tracking measurement for early detecting cognitive impairment

   AAIC 2025 abstract·24 Dec 2025

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1. Tau PET is associated with tau deposition in humans (49% (N = 112)).

   “Among those with Aβ >24CL ( N = 229), those who also had tau > 1.2 SUVr ( N = 112, 49%) had increasing tau”

   Humansin individuals with amyloid-beta > 24 CL and baseline tau > 1.2 SUVr

   Alzheimer's Disease Trajectory and the In Vivo Anatomy of Tau Progression

   AAIC 2025 abstract·24 Dec 2025

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1. Amyloid-beta is associated with tau deposition in humans.

   “In both analyses, Aβ+ individuals showed higher tau deposition in Braak I and Braak III regions.”

   HumansAβ+ (Centiloid > 20) vs Aβ-brain

   Spatiotemporal associations between amyloid and tau pathologies in preclinical Alzheimer’s disease

   AAIC 2025 abstract·23 Dec 2025

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