AD-signature region cerebral glucose metabolism

1. Decreasing body mass index decreases AD-signature region cerebral glucose metabolism in humans (β = 0.029; 95% CI, 0.003 to 0.055; p = .027).

   “Participants with decreasing BMI patterns from midlife to late life exhibited significantly lower AD-CM compared to those with increasing patterns (β = 0.029; 95% CI, 0.003 to 0.055; p = .027).”

   Humansnon-demented older adults, decreasing vs increasing patternsbrainn = 268

   BMI changes from midlife to late life and their relationship with Alzheimer's disease pathologies

   Alzheimer's research & therapy·23 Jan 2026

More on Decreasing body mass index

1. Midlife body mass index decreases AD-signature region cerebral glucose metabolism in humans (β = − 0.009; 95% CI, − 0.015 to − 0.003; p < .01).

   “Higher midlife BMI correlated significantly with lower AD-CM (β = − 0.009; 95% CI, − 0.015 to − 0.003; p < .01).”

   Humansnon-demented older adultsbrainn = 268

   BMI changes from midlife to late life and their relationship with Alzheimer's disease pathologies

   Alzheimer's research & therapy·23 Jan 2026

More on Midlife body mass index