Mesenchymal stem cell secretome

1. Mesenchymal stem cell secretome protects against neurodegenerative disease.

   “Preclinical and clinical data indicate that secretome-based products exert potent regenerative effects in osteoarthritis, chronic wounds, stroke, traumatic brain injury, and neurodegenerative diseases.”

   Review

   Collecting Eggs, Not Killing Chickens: Why Stem Cell Secretome and Exosomes Are Redefining Regenerative Medicine for Healthspan Extension

   Biomedicines·9 Apr 2026

More on Neurodegenerative disease

1. Mesenchymal stem cell secretome protects against osteoarthritis.

   “Preclinical and clinical data indicate that secretome-based products exert potent regenerative effects in osteoarthritis, chronic wounds, stroke, traumatic brain injury, and neurodegenerative diseases.”

   Review

   Collecting Eggs, Not Killing Chickens: Why Stem Cell Secretome and Exosomes Are Redefining Regenerative Medicine for Healthspan Extension

   Biomedicines·9 Apr 2026

More on Osteoarthritis

1. Mesenchymal stem cell secretome improves kidney function.

   “facilitating tissue repair via anti-inflammatory, anti-fibrosis, anti-apoptotic, and pro-angiogenesis effects, thereby improving kidney function and mitigating disease progression.”

   Reviewkidney diseaseskidney

   Targeting cellular senescence in kidney diseases and aging: A focus on mesenchymal stem cells and their paracrine factors

   Cell communication and signaling : CCS·18 Dec 2024

1. Mesenchymal stem cell secretome increases neuronal density in mice.

   “We found a higher neuronal density in cortex and hippocampus, associated with a reduction in hippocampal shrinkage”

   AnimalsAPP/PS1 AD micecortex and hippocampus

   Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer's mice

   Cell death and differentiation·23 Jul 2020

More on Neuronal density

1. Mesenchymal stem cell secretome extends lifespan in mice.

   “associated with a reduction in hippocampal shrinkage and a longer lifespan indicating healthier conditions of MSC-CS-treated compared to vehicle-treated APP/PS1 mice”

   AnimalsAPP/PS1 AD mice

   Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer's mice

   Cell death and differentiation·23 Jul 2020

1. Mesenchymal stem cell secretome decreases amyloid plaques in mice.

   “with dramatic reduction of plaques surrounded by a lower density of β-amyloid oligomers”

   AnimalsAPP/PS1 AD mice

   Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer's mice

   Cell death and differentiation·23 Jul 2020

More on Amyloid plaques

1. Mesenchymal stem cell secretome improves memory recovery in mice.

   “Once-weekly intranasal administration of MSC-CS induced persistent memory recovery”

   AnimalsAPP/PS1 AD mice

   Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer's mice

   Cell death and differentiation·23 Jul 2020