Lysophosphatidic acid
Across all fields, 2 papers: none in people yet, 1 in animals, 1 in cells
- 3 independent labs in 3 countries
- Funders: American Heart Association and 3 more
- Animals1
- Cells1
Outcomes
2Nuclear localization of GAPDH
downin human cells1
1 study
Nuclear localization of GAPDH
downin human cells1
Lysophosphatidic acid decreases nuclear localization of GAPDH in human cells.
“Senescence-induced nuclear localization was reversed by lysophosphatidic acid”
Cellsfibroblast
Aging
Vasoconstrictor responses
upin rats1
1 study
Vasoconstrictor responses
upin rats1
Lysophosphatidic acid improves vasoconstrictor responses in rats.
“In the presence of LPA, vasoconstrictor responses to Ang II were improved in old SFA such that responses were not different than young P90 SFA.”
Animalsex vivo; responses to angiotensin IIsoleus muscle feed artery
European journal of applied physiology
Associations
1Cell motility
mixedin human cells1
1 study
Cell motility
mixedin human cells1
Lysophosphatidic acid is associated with cell motility in human cells.
“The sensitivity of cell motility metrics to the impact of LPA varied depending on their origin, with the most pronounced effects observed during the initial passages.”
Cellsduring initial passages
Stem cell reviews and reports
Latest
7 papers in 12 monthsJournal of Exposure Science & Environmental Epidemiology
Association between ambient temperature and thrombosis-related signaling lipids: Implications for early cardiovascular risk
Cohort study of 112 peopleThrombosis
Frontiers in Medicine
Lipoprotein(a) and calcific aortic stenosis: from inherited risk marker to therapeutic target
ReviewMechanisms
International Journal of Molecular Sciences
Role of Lipoprotein(a) in Aortic Valve Calcification: Inflammatory and Oxidative Mechanisms Involved
ReviewMechanisms
Frontiers in Neuroscience
Untargeted plasma metabolomics in canine cognitive dysfunction: the naturally occurring Alzheimer's disease analog in dogs
Study of 10 dogsBiomarkers
Neurotoxicology
Cadmium exposure at low environmental levels induces cognitive decline in aged male mice
Experiments in miceMechanisms
iScience
Targeting phospholipase PLAG-15 promotes healthy aging in C. elegans via lysosomal-related genes
Experiments in wormsLysosome
Stem Cell Reviews and Reports
It's Not Just About Speed: Single-Cell Tracking Reveals Changes in MSC Motility Associated with Replicative Senescence
Experiments in human cellsCellular senescence