OCIAD1
1 paper studies it2 findings
- 1 lab in 1 country
- Funders: Department of Biotechnology, Ministry of Science and Technology, India and 2 more
- Animals1
Effects
2Ubiquitin–proteasome system
upin mice1
1 study
Ubiquitin–proteasome system
upin mice1
OCIAD1 activates ubiquitin–proteasome system in mice.
“analysis of organelle structure and function in asrij KO mice revealed significant changes, namely damaged mitochondria, elevated ROS; impaired endosomal trafficking seen by increased cleaved Notch1, reduced Rab5; and reduced 26S proteasome activity.”
Animalsshown by knockout
Aging cell
Hematopoietic stem cell quiescence
is required forin mice1
1 study
Hematopoietic stem cell quiescence
is required forin mice1
OCIAD1 is required for hematopoietic stem cell quiescence in mice.
“Asrij deletion in mice causes loss of HSC quiescence, myeloid skewing, reduced p53 and increased DNA damage, features attributed to aged HSCs.”
Animalsshown by knockout
Aging cell