Low-molecular-weight hyaluronic acid

Intervention

1 paper2 findings

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Outcomes

2

PI3K–AKT signalling

downin cells1

1 study
  1. Low-molecular-weight hyaluronic acid inhibits PI3K–AKT signalling in cells.

    “engagement of CD44 by LMW-HA suppressed AKT phosphorylation”

    Cellsin vitronucleus pulposus

    HYAL2-generated low-molecular-weight hyaluronic acid promotes intervertebral disc degeneration via the CD44/AKT signaling axis

    Biochemical and biophysical research communications6 Mar 2026

More on PI3K–AKT signalling

Cellular senescence

upin cells1

1 study
  1. Low-molecular-weight hyaluronic acid induces cellular senescence in cells.

    “HYAL2 overexpression and exogenous LMW-HA both induced nucleus pulposus (NP) cell senescence, inflammatory activation and ECM degradation.”

    Cellsnucleus pulposus

    HYAL2-generated low-molecular-weight hyaluronic acid promotes intervertebral disc degeneration via the CD44/AKT signaling axis

    Biochemical and biophysical research communications6 Mar 2026

More on Cellular senescence

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