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Lentiviral mtert

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Cancer Prevention and Research Institute of Texas and 2 more
  • Animals1

Outcomes

2

DNA damage

downin mice1

1 study

  1. Lentiviral mtert decreases DNA damage in mice.

    “Progeria mice treated with mTERT lentivirus manifested similar improvements, with a reduction in inflammatory and DNA damage markers”

    Animalsin HGPS mice

    Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice

    European heart journalNov 7, 2021

More on DNA damage

Lifespan

upin mice1

1 study

  1. Lentiviral mtert extends lifespan in mice.

    “Furthermore, mTERT therapy increased the lifespan of HGPS mice.”

    Animalsin HGPS mice

    Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice

    European heart journalNov 7, 2021

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