Lactobacillus murinus

Intervention

2 papers3 findings

  • 1 lab in 1 country
  • Funders: National Institutes of Health and 2 more
  • Animals2

Outcomes

3

Inflammation

downin mice1

1 study
  1. Lactobacillus murinus decreases inflammation in mice.

    “decreased their intestinal permeability and serum endotoxin load, consequently attenuating the inflammation induced by the old microbiota.”

    Animalsin gnotobiotic mice colonized with gut microbiota from old mice

    Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

    Microbiome21 Mar 2018

More on Inflammation

Lifespan

upin worms1

1 study
  1. Lactobacillus murinus extends lifespan in worms.

    “significantly increased the lifespan and the brood size of the nematode Caenorhabditis elegans.”

    Model organismsin C. elegans

    Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

    Microbiome21 Mar 2018

INTERLEUKIN-8

downin human cells1

1 study
  1. Lactobacillus murinus decreases INTERLEUKIN-8 in human cells.

    “downregulated interleukin-8 production in TNF-α-stimulated Caco-2 cells”

    Cellsin TNF-α-stimulated Caco-2 cells

    Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice

    Microbiome21 Mar 2018

More on INTERLEUKIN-8

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Cell Death Discovery

Gut microbial bile acid reduced muscle wasting in diabetic mice

In an animal experiment, 7-ketodeoxycholic acid also restored muscle function and enhanced exercise capacity in mice with type 2 diabetes.In an animal experiment, 7-ketodeoxycholic acid also restored muscle function and enhanced exercise capacity in mice with type 2 diabetes.

Experiments in mice with type 2 diabetesGut and microbiome