1 paper5 findings
Ferroptosis
downin mouse cells1
7-ketodeoxycholic acid inhibits ferroptosis in mouse cells.
“RNA sequencing and experimental analysis revealed that 7-KDCA inhibited NLRP1 inflammasome activation to suppress ferroptosis in myotubes”
Cellsmyotube
Gut microbial bile acid reduced muscle wasting in diabetic mice
Cell death discovery14 Oct 2026
NLRP1 inflammasome activation
downin mouse cells1
7-ketodeoxycholic acid inhibits NLRP1 inflammasome activation in mouse cells.
“RNA sequencing and experimental analysis revealed that 7-KDCA inhibited NLRP1 inflammasome activation to suppress ferroptosis in myotubes”
Cellsmyotube
Gut microbial bile acid reduced muscle wasting in diabetic mice
Cell death discovery14 Oct 2026
Glucose intolerance
downin mice1
7-ketodeoxycholic acid decreases glucose intolerance in mice.
“Administration of 7-KDCA ameliorated glucose intolerance, attenuated muscle atrophy, restored muscle function, enhanced exercise capacity, and improved intestinal permeability in T2DM mice.”
AnimalsT2DM mice
Gut microbial bile acid reduced muscle wasting in diabetic mice
Cell death discovery14 Oct 2026
Muscle function
upin mice1
7-ketodeoxycholic acid improves muscle function in mice.
“Administration of 7-KDCA ameliorated glucose intolerance, attenuated muscle atrophy, restored muscle function, enhanced exercise capacity, and improved intestinal permeability in T2DM mice.”
AnimalsT2DM miceskeletal muscle
Gut microbial bile acid reduced muscle wasting in diabetic mice
Cell death discovery14 Oct 2026
Muscle atrophy
downin mice1
7-ketodeoxycholic acid decreases muscle atrophy in mice.
“Administration of 7-KDCA ameliorated glucose intolerance, attenuated muscle atrophy, restored muscle function, enhanced exercise capacity, and improved intestinal permeability in T2DM mice.”
AnimalsT2DM miceskeletal muscle
Gut microbial bile acid reduced muscle wasting in diabetic mice
Cell death discovery14 Oct 2026
In an animal experiment, 7-ketodeoxycholic acid also restored muscle function and enhanced exercise capacity in mice with type 2 diabetes.In an animal experiment, 7-ketodeoxycholic acid also restored muscle function and enhanced exercise capacity in mice with type 2 diabetes.