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Ivacaftor

Ivacaftor has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest story, Oct 31, 2026: “Ivacaftor reduced experimental lung scarring in mice”.

Intervention

1 paper studies it5 findingsUpdated

PubChemChEBI

1 new paper in 30 daysSee all 1

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

About aging: trials about aging, of every trial that tests the drug for any use.

No results posted: trials that ended over a year ago with no results on ClinicalTrials.gov and no paper reporting them.

  • 1 lab
  • 1 trial, none about aging, 1 with no results posted
  • Animals1

What did studies of Ivacaftor find?

4

Studies of Ivacaftor measured 4 outcomes; the most studied are cellular senescence (1 study), PI3K–AKT signaling (1) and epithelial homeostasis (1).

Cellular senescence

downin cells1downin mice1

1 study

  1. Ivacaftor decreases cellular senescence in cells.

    “VX-770 diminished cellular senescence both in vivo and in AT2 cell organoid cultures”

    Cellsalveolar type 2 cell organoid

    Ivacaftor reduced experimental lung scarring in mice

    Cell death discovery

  2. Ivacaftor decreases cellular senescence in mice (bleomycin-induced pulmonary fibrosis).

    “VX-770 diminished cellular senescence both in vivo and in AT2 cell organoid cultures”

    Animalsbleomycin-induced pulmonary fibrosisalveolar type 2 cell

    Ivacaftor reduced experimental lung scarring in mice

    Cell death discovery

More on Cellular senescence

PI3K–AKT signaling

downin mice1

1 study

  1. Ivacaftor inhibits PI3K–AKT signaling in mice.

    “VX-770 stabilized the CFTR-PTEN protein complex, elevating PTEN levels and thereby inhibiting the profibrotic PI3K/AKT signaling pathway.”

    Animals

    Ivacaftor reduced experimental lung scarring in mice

    Cell death discovery

More on PI3K–AKT signaling

epithelial homeostasis

upin mice1

1 study

  1. Ivacaftor improves epithelial homeostasis in mice (bleomycin-induced pulmonary fibrosis).

    “The treatment reestablished epithelial homeostasis, decreasing aberrant KRT8 + transitional cells and preventing the loss of alveolar type 1 cells.”

    Animalsbleomycin-induced pulmonary fibrosislung

    Ivacaftor reduced experimental lung scarring in mice

    Cell death discovery

Pulmonary fibrosis

downin mice1

1 study

  1. Ivacaftor decreases pulmonary fibrosis in mice (bleomycin-induced pulmonary fibrosis).

    “VX-770 treatment reduced pulmonary fibrosis by limiting collagen deposition and restoring normal lung structure and function.”

    Animalsbleomycin-induced pulmonary fibrosislung

    Ivacaftor reduced experimental lung scarring in mice

    Cell death discovery

More on Pulmonary fibrosis

Trial sponsors

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 1Nov 2026: 01 paper in 12 months
Cell Death Discovery

Ivacaftor reduced experimental lung scarring in mice

In mice with chemically induced lung scarring, the drug reduced collagen buildup and restored normal lung structure and function.In mice with chemically induced lung scarring, the drug reduced collagen buildup and restored normal lung structure and function.

Mouse studyLung
Paper

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