Isoproterenol
- 2 independent labs in 2 countries
- Funders: National Key Research and Development Program of China and 1 more
- Animals2
Outcomes
5Chronic heart failure
upin rats1
1 study
Chronic heart failure
upin rats1
Isoproterenol induces chronic heart failure in rats.
“Histological examination of myocardial, renal, pulmonary, and brain tissues revealed changes characteristic of chronic heart failure.”
Animals10 mg/kg, four injections60 daysmales
Advances in gerontology = Uspekhi gerontologii1 Jan 2026
Myocardial contractility
no changein rats1
1 study
Myocardial contractility
no changein rats1
Isoproterenol has no effect on myocardial contractility in rats.
“no statistically significant differences were observed in contractility parameters of isolated perfused hearts between the groups”
Animalsin isolated perfused hearts 60 days after final injectionmyocardiummales
Advances in gerontology = Uspekhi gerontologii1 Jan 2026
Heart rate
upin rats1
1 study
Heart rate
upin rats1
Isoproterenol increases heart rate in rats.
“Heart rate was significantly higher in the experimental group compared with controls.”
Animalsisoproterenol-induced chronic heart failure60 days after final injectionmales
Advances in gerontology = Uspekhi gerontologii1 Jan 2026
Lifespan
upin mice1+21%
1 study
Lifespan
upin mice1+21%
Isoproterenol extends lifespan in mice (~21%).
“extended the mean lifespan of HGPS mice by ~21%”
Animalsin HGPS mice
Impaired end joining induces cardiac atrophy in a Hutchinson-Gilford progeria mouse model
Proceedings of the National Academy of Sciences of the United States of America15 Nov 2023
Cardiac atrophy
downin mice1
1 study
Cardiac atrophy
downin mice1
Isoproterenol decreases cardiac atrophy in mice.
“isoproterenol treatment significantly reduced AMPKα and FOXO3A phosphorylation in the heart, attenuated the atrophy phenotype”
Animalsin HGPS miceheart
Impaired end joining induces cardiac atrophy in a Hutchinson-Gilford progeria mouse model
Proceedings of the National Academy of Sciences of the United States of America15 Nov 2023