FOXF1

Gene

1 paper3 findings

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Humans1

Effects

3

EZH2

upin cells1

1 study
  1. FOXF1 activates EZH2 in cells.

    “FOXF1 was identified to be a transcriptional activator of EZH2”

    Cells

    DKK3, regulated by FOXF1-EZH2 axis, takes action on tubular epithelial cells senescence to trigger glomerular endothelial cells ferroptosis involving in renal fibrosis

    Mechanisms of ageing and development28 Aug 2025

More on EZH2

Renal fibrosis

downin mice1

1 study
  1. FOXF1 decreases renal fibrosis in mice.

    “In UUO mice, FOXF1 depletion worsened renal fibrosis and senescence.”

    AnimalsUUO mice; shown by FOXF1 depletionkidney

    DKK3, regulated by FOXF1-EZH2 axis, takes action on tubular epithelial cells senescence to trigger glomerular endothelial cells ferroptosis involving in renal fibrosis

    Mechanisms of ageing and development28 Aug 2025

More on Renal fibrosis

Tubular cell senescence

downin cells1

1 study
  1. FOXF1 decreases tubular cell senescence in cells.

    “Reinforced FOXF1 protected against H2O2-triggered tubular cell damage, fibrosis, and senescence, which was reversed by DKK3 overexpression.”

    CellsH2O2 exposure; FOXF1 reinforcement, with protection reversed by DKK3 overexpressiontubular epithelial cell

    DKK3, regulated by FOXF1-EZH2 axis, takes action on tubular epithelial cells senescence to trigger glomerular endothelial cells ferroptosis involving in renal fibrosis

    Mechanisms of ageing and development28 Aug 2025

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