FOXF1
1 paper3 findings
- 1 lab in 1 country
- Funder: National Natural Science Foundation of China
- Humans1
Effects
3EZH2
upin cells1
1 study
EZH2
upin cells1
FOXF1 activates EZH2 in cells.
“FOXF1 was identified to be a transcriptional activator of EZH2”
Cells
Mechanisms of ageing and development28 Aug 2025
Renal fibrosis
downin mice1
1 study
Renal fibrosis
downin mice1
FOXF1 decreases renal fibrosis in mice.
“In UUO mice, FOXF1 depletion worsened renal fibrosis and senescence.”
AnimalsUUO mice; shown by FOXF1 depletionkidney
Mechanisms of ageing and development28 Aug 2025
Tubular cell senescence
downin cells1
1 study
Tubular cell senescence
downin cells1
FOXF1 decreases tubular cell senescence in cells.
“Reinforced FOXF1 protected against H2O2-triggered tubular cell damage, fibrosis, and senescence, which was reversed by DKK3 overexpression.”
CellsH2O2 exposure; FOXF1 reinforcement, with protection reversed by DKK3 overexpressiontubular epithelial cell
Mechanisms of ageing and development28 Aug 2025
Latest
Mechanisms of Ageing and Development
DKK3, regulated by FOXF1-EZH2 axis, takes action on tubular epithelial cells senescence to trigger glomerular endothelial cells ferroptosis involving in renal fibrosis
Study in peopleFerroptosis