Hng
Hng has been studied in 8 papers since 2017: none in people yet, 4 in animals, 3 in cells, 1 review; 1 in the past year. The research so far is in animals and cells. The newest paper, Jul 16, 2022: “Humanin derivative, HNG, enhances neurotransmitter release”.
8 papers study it17 findingsUpdated
- 7 independent labs in 4 countries
- Funders: Japan Society for the Promotion of Science and others
- 2 of 17 findings with company ties
- Animals4
- Cells3
What did studies of Hng find?
16Studies of Hng measured 16 outcomes; the most studied are apoptosis (2 studies), fusion index (1) and myotube area (1).
Apoptosis
downin human cells1downin rats1
2 studies
Apoptosis
downin human cells1downin rats1
Hng inhibits apoptosis in human cells.
“In AMD cybrids, HNG protected the AMD mitochondria, reduced pro-apoptosis gene and protein levels, upregulated gp130 (a component of the HN receptor complex), and increased the protection against amyloid-β-induced damage.”
Cellsin transmitochondrial ARPE-19 cybrids
Cell death & disease
Hng inhibits apoptosis in rats (Bax (0.26 ± 0.01 vs. 0.29 ± 0.008, P < 0.01) and Caspase-3 (0.20 ± 0.008 vs. 0.24 ± 0.02, P < 0.01)).
“HNG might exert neuroprotective effects through alleviating apoptosis”
Animalsglobal cerebral ischemia/reperfusionhippocampus
Neurological research
Fusion index
no changein human cells1
1 study
Fusion index
no changein human cells1
Hng has no effect on fusion index in human cells.
“had no effect on fusion index or E3 ligase mRNA levels”
Cellsin dexamethasone-treated cellsskeletal muscle10 μM
Physiological reports
Myotube area
downin human cells1
1 study
Myotube area
downin human cells1
Hng prevents myotube area in human cells (p < 0.001).
“HNG co-treatment with DEXA preserved myotube area (p < 0.001)”
Cellsin dexamethasone-treated cellsskeletal muscle10 μM
Physiological reports
Dopamine release
upin cells1
1 study
Dopamine release
upin cells1
Hng increases dopamine release in cells.
“In a neuronal cell model, rat pheochromocytoma PC12 cells, HNG enhanced ACh-induced dopamine release.”
CellsACh-inducedPC12 cells
Humanin derivative, HNG, enhances neurotransmitter release
Biochimica et biophysica acta. General subjects
Object memory
upin animals1
1 study
Object memory
upin animals1
Hng improves object memory.
“modestly improved their object memory.”
Animals
Humanin derivative, HNG, enhances neurotransmitter release
Biochimica et biophysica acta. General subjects
Physical activity
no changein animals1
1 study
Physical activity
no changein animals1
Hng has no effect on physical activity.
“HNG did not affect the physical activities of the mice”
Animals
Humanin derivative, HNG, enhances neurotransmitter release
Biochimica et biophysica acta. General subjects
Acetylcholine
upin animals1
1 study
Acetylcholine
upin animals1
Hng increases acetylcholine.
“The hippocampal acetylcholine (ACh) levels were increased by intraperitoneal injection of HNG.”
Animalsintraperitoneal injectionhippocampus
Humanin derivative, HNG, enhances neurotransmitter release
Biochimica et biophysica acta. General subjects
EGR1
downin human cells1
1 study
EGR1
downin human cells1
Hng decreases EGR1 in human cells.
“treatment with HNG attenuated UV-B-induced expression of Egr-1”
Cellsin UV-B-induced HRECsretinal endothelial cells
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
IL-1β
downin human cells1
1 study
IL-1β
downin human cells1
Hng decreases IL-1β in human cells.
“mitigated the excessive release of IL-1β and IL-18 in UV-B-challenged HRECs”
Cellsin UV-B-challenged HRECsretinal endothelial cells
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
NLRP3 inflammasome
downin human cells1
1 study
NLRP3 inflammasome
downin human cells1
Hng inhibits NLRP3 inflammasome in human cells.
“treatment with HNG inhibited the activation of the TXNIP/NLRP3 signaling pathway”
Cellsin UV-B-challenged HRECsretinal endothelial cells
Inflammation research : official journal of the European Histamine Research Society ... [et al.]