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High-intensity knee-extension exercise

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 2 more
  • Human trial1

Outcomes

2

natural killer cell-mediated immune processes

upin humans1

1 study

  1. High-intensity knee-extension exercise activates natural killer cell-mediated immune processes in humans.

    “Notably, exercise elicited shared activation of NK cell-mediated processes across age groups”

    Human trialBoth age groupsperipheral blood mononuclear cellSingle boutImmediately after exercise

    Transcriptomic analyses of peripheral blood mononuclear cells reveal age-specific basal and acute exercise responsiveness differences in humans

    American journal of physiology. Endocrinology and metabolism22 Jul 2025

Expression of genes linked to cellular dysfunction and suppressed immune function

downin humans1

1 study

  1. High-intensity knee-extension exercise decreases expression of genes linked to cellular dysfunction and suppressed immune function in humans.

    “acute exercise attenuated these age-related differences by downregulating the genes related to those pathways.”

    Human trialAge-related gene expression differencesperipheral blood mononuclear cellSingle boutImmediately after exercise

    Transcriptomic analyses of peripheral blood mononuclear cells reveal age-specific basal and acute exercise responsiveness differences in humans

    American journal of physiology. Endocrinology and metabolism22 Jul 2025

More on Expression of genes linked to cellular dysfunction and suppressed immune function

Associations

1

PBMC gene expression

mixedin humans1

1 study

  1. High-intensity knee-extension exercise is associated with PBMC gene expression in humans (53 differentially expressed genes in young versus 1,026 in older individuals).

    “After the exercise bout, 53 genes were differentially expressed in young, whereas 1,026 genes changed in old.”

    Human trialYoung and older individualsperipheral blood mononuclear cellSingle boutImmediately after exercise

    Transcriptomic analyses of peripheral blood mononuclear cells reveal age-specific basal and acute exercise responsiveness differences in humans

    American journal of physiology. Endocrinology and metabolism22 Jul 2025

More on PBMC gene expression

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