PBMC gene expression

1. High-intensity knee-extension exercise is associated with PBMC gene expression in humans (53 differentially expressed genes in young versus 1,026 in older individuals).

   “After the exercise bout, 53 genes were differentially expressed in young, whereas 1,026 genes changed in old.”

   Human trialYoung and older individualsperipheral blood mononuclear cellSingle boutImmediately after exercise

   Transcriptomic analyses of peripheral blood mononuclear cells reveal age-specific basal and acute exercise responsiveness differences in humans

   American journal of physiology. Endocrinology and metabolism·22 Jul 2025

More on High-intensity knee-extension exercise

1. Older age is associated with PBMC gene expression in humans (665 differentially expressed genes).

   “At baseline, 665 genes differed between young and old”

   Human trialOlder versus young individualsperipheral blood mononuclear cellBaseline

   Transcriptomic analyses of peripheral blood mononuclear cells reveal age-specific basal and acute exercise responsiveness differences in humans

   American journal of physiology. Endocrinology and metabolism·22 Jul 2025