Heat shock protein 70

1. Heat shock protein 70 extends lifespan in mice.

   “Long-term administration of eHsp70 significantly enhanced the lifespan of animals of different age groups.”

   Animalsbrain

   Exogenous Hsp70 delays senescence and improves cognitive function in aging mice

   Proceedings of the National Academy of Sciences of the United States of America·14 Dec 2015

2. Heat shock protein 70 extends lifespan in mice.

   “The administration of rhHsp70 was effective at increasing lifespan, delaying symptom onset, preserving motor function and prolonging MN survival.”

   AnimalsG93A mutant SOD1 micebeginning at postnatal day 50 until endstage

   Exogenous delivery of heat shock protein 70 increases lifespan in a mouse model of amyotrophic lateral sclerosis

   The Journal of neuroscience : the official journal of the Society for Neuroscience·28 Nov 2007

1. Heat shock protein 70 increases ubiquitin–proteasome system in mice.

   “enhanced proteasome activity.”

   Animalsbrain

   Exogenous Hsp70 delays senescence and improves cognitive function in aging mice

   Proceedings of the National Academy of Sciences of the United States of America·14 Dec 2015

More on Ubiquitin–proteasome system

1. Heat shock protein 70 decreases lipofuscin in mice.

   “eHsp70 treatment decreased accumulation of lipofuscin, an aging-related marker, in the brain”

   Animalsbrain

   Exogenous Hsp70 delays senescence and improves cognitive function in aging mice

   Proceedings of the National Academy of Sciences of the United States of America·14 Dec 2015

More on Lipofuscin

1. Heat shock protein 70 improves locomotor and exploratory activities in mice.

   “the investigation of locomotor and exploratory activities after eHsp70 treatment demonstrated a significant therapeutic effect of this chaperone.”

   Animals

   Exogenous Hsp70 delays senescence and improves cognitive function in aging mice

   Proceedings of the National Academy of Sciences of the United States of America·14 Dec 2015

1. Heat shock protein 70 improves learning and memory in mice.

   “Behavioral assessment after 5 and 9 mo of chronic eHsp70 administration demonstrated improved learning and memory in old mice.”

   Animals5 and 9 mo

   Exogenous Hsp70 delays senescence and improves cognitive function in aging mice

   Proceedings of the National Academy of Sciences of the United States of America·14 Dec 2015

1. Heat shock protein 70 increases innervated neuromuscular junctions in mice.

   “Treatment with rhHsp70 also resulted in an increased number of innervated neuromuscular junctions compared with control tissue.”

   AnimalsG93A mutant SOD1 micebeginning at postnatal day 50 until endstage

   Exogenous delivery of heat shock protein 70 increases lifespan in a mouse model of amyotrophic lateral sclerosis

   The Journal of neuroscience : the official journal of the Society for Neuroscience·28 Nov 2007

More on Innervated neuromuscular junctions

1. Heat shock protein 70 improves motoneuron survival in mice.

   “administration of rhHsp70 was effective at increasing lifespan, delaying symptom onset, preserving motor function and prolonging MN survival.”

   AnimalsG93A mutant SOD1 micebeginning at postnatal day 50 until endstage

   Exogenous delivery of heat shock protein 70 increases lifespan in a mouse model of amyotrophic lateral sclerosis

   The Journal of neuroscience : the official journal of the Society for Neuroscience·28 Nov 2007

1. Heat shock protein 70 improves motor function in mice.

   “administration of rhHsp70 was effective at increasing lifespan, delaying symptom onset, preserving motor function and prolonging MN survival.”

   AnimalsG93A mutant SOD1 micebeginning at postnatal day 50 until endstage

   Exogenous delivery of heat shock protein 70 increases lifespan in a mouse model of amyotrophic lateral sclerosis

   The Journal of neuroscience : the official journal of the Society for Neuroscience·28 Nov 2007

1. Heat shock protein 70 decreases symptom onset in mice.

   “administration of rhHsp70 was effective at increasing lifespan, delaying symptom onset, preserving motor function and prolonging MN survival.”

   AnimalsG93A mutant SOD1 micebeginning at postnatal day 50 until endstage

   Exogenous delivery of heat shock protein 70 increases lifespan in a mouse model of amyotrophic lateral sclerosis

   The Journal of neuroscience : the official journal of the Society for Neuroscience·28 Nov 2007