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Green tea catechins

Intervention

4 papers9 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 3 independent labs in 1 country
  • 1 finding against
  • Funders: Shizuoka University and 3 more
  • 1 of 8 findings with company ties
  • Animals4

Outcomes

8

Lifespan

upin mice1no changein mice1

2 studies

  1. Green tea catechins extend lifespan in mice.

    “intake of 1 mg/kg or more suppressed cognitive decline and a shortened lifespan.”

    Animals1 mg/kg or more

    Green Tea Catechins Trigger Immediate-Early Genes in the Hippocampus and Prevent Cognitive Decline and Lifespan Shortening

    Molecules (Basel, Switzerland)25 Mar 2020

  2. Green tea catechins have no effect on lifespan in mice.

    “GT-catechin did not prolong the lifetime of SAMP10 mice”

    AnimalsSAMP10 micewater containing 0.02% GT-catechin35 mg/kg/day

    Daily consumption of green tea catechin delays memory regression in aged mice

    Biogerontology7 Sep 2006

Sarcopenia

downin mice1

1 study

  1. Green tea catechins decrease sarcopenia in mice.

    “The GTCs and/or Ex groups showed improved symptoms and pathologies of sarcopenia.”

    Animalsvoluntary wheel running and/or 0.33 % GTCs dietskeletal muscle12 weeksmales

    Effects of green tea catechins and exercise on age-related muscle atrophy and satellite cell functions in a mouse model of sarcopenia

    Experimental gerontology25 Feb 2025

More on Sarcopenia

EGR1

upin mice1

1 study

  1. Green tea catechins increase EGR1 in mice.

    “expression of immediate-early genes such as nuclear receptor subfamily 4 (Nr4a), FBJ osteosarcoma oncogene (Fos), early growth response 1 (Egr1), neuronal PAS domain protein 4 (Npas4), and cysteine-rich protein 61 (Cyr61) was significantly increased.”

    Animalshippocampusone month

    Green Tea Catechins Trigger Immediate-Early Genes in the Hippocampus and Prevent Cognitive Decline and Lifespan Shortening

    Molecules (Basel, Switzerland)25 Mar 2020

More on EGR1

Cognitive function

upin mice1

1 study

  1. Green tea catechins improve cognitive function in mice.

    “intake of 1 mg/kg or more suppressed cognitive decline and a shortened lifespan.”

    Animals1 mg/kg or more

    Green Tea Catechins Trigger Immediate-Early Genes in the Hippocampus and Prevent Cognitive Decline and Lifespan Shortening

    Molecules (Basel, Switzerland)25 Mar 2020

Oxidative stress and ROS signalling

downin mice1

1 study

  1. Green tea catechins decrease oxidative stress and ROS signalling in mice.

    “GT-catechin), potent antioxidants, decrease oxidative damage to DNA and suppress brain dysfunction in aged senescence-accelerated mice (SAMP10) when ingested from the age of 1 month to the age of 12 months.”

    Reviewin SAMP10 mice

    Daily ingestion of green tea catechins from adulthood suppressed brain dysfunction in aged mice

    BioFactors (Oxford, England)1 Jan 2008

More on Oxidative stress and ROS signalling

Learning ability

upin mice1

1 study

  1. Green tea catechins improve learning ability in mice.

    “Learning ability was significantly higher in mice that ingested GT-catechin from the age of 6 months to 12 months when compared with same-aged control mice drank water without GT-catechin.”

    Animalsin SAMP10 mice0.02%6 months

    Daily ingestion of green tea catechins from adulthood suppressed brain dysfunction in aged mice

    BioFactors (Oxford, England)1 Jan 2008

DNA oxidative damage

downin mice1

1 study

  1. Green tea catechins prevent DNA oxidative damage in mice.

    “daily consumption of GT-catechin prevented memory regression and DNA oxidative damage in these mice”

    AnimalsSAMP10 micewater containing 0.02% GT-catechin35 mg/kg/day

    Daily consumption of green tea catechin delays memory regression in aged mice

    Biogerontology7 Sep 2006

More on DNA oxidative damage

Memory regression

downin mice1

1 study

  1. Green tea catechins prevent memory regression in mice.

    “daily consumption of GT-catechin prevented memory regression and DNA oxidative damage in these mice”

    AnimalsSAMP10 micewater containing 0.02% GT-catechin35 mg/kg/day

    Daily consumption of green tea catechin delays memory regression in aged mice

    Biogerontology7 Sep 2006

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