Ginsenoside RG5

1. Ginsenoside RG5 decreases aging-associated phenotypes in worms.

   “alleviates aging-associated phenotypes in both cells and nematodes.”

   Model organisms

   Ginsenoside Rg5 targets the KAT8-CISD2 axis to maintain mitochondrial homeostasis and antagonize senescence

   Phytomedicine : international journal of phytotherapy and phytopharmacology·5 Feb 2026

1. Ginsenoside RG5 increases cellular homeostasis in worm cells.

   “ginsenoside Rg5 directly binds to KAT8, promotes CISD2 acetylation at the K74 site, maintaining mitochondrial homeostasis, and alleviates aging-associated phenotypes in both cells and nematodes.”

   Cells

   Ginsenoside Rg5 targets the KAT8-CISD2 axis to maintain mitochondrial homeostasis and antagonize senescence

   Phytomedicine : international journal of phytotherapy and phytopharmacology·5 Feb 2026

More on Cellular homeostasis

1. Ginsenoside RG5 decreases oxidative stress and ROS signalling in worms.

   “Four ginsenoside derivatives showed different activities of delaying aging by improving muscle function, enhancing anti-oxidant stress, and reducing AChE activity in C. elegans.”

   Model organismsin C. elegans

   Structure-activity relationship of ginsenoside derivatives with different glycosides and double bond position on anti-aging bioactivities

   Journal of ginseng research·9 May 2025

More on Oxidative stress and ROS signalling

1. Ginsenoside RG5 decreases acetylcholinesterase activity in worms.

   “Four ginsenoside derivatives showed different activities of delaying aging by improving muscle function, enhancing anti-oxidant stress, and reducing AChE activity in C. elegans.”

   Model organismsin C. elegans

   Structure-activity relationship of ginsenoside derivatives with different glycosides and double bond position on anti-aging bioactivities

   Journal of ginseng research·9 May 2025

More on Acetylcholinesterase activity

1. Ginsenoside RG5 improves muscle function in worms.

   “Four ginsenoside derivatives showed different activities of delaying aging by improving muscle function, enhancing anti-oxidant stress, and reducing AChE activity in C. elegans.”

   Model organismsin C. elegans

   Structure-activity relationship of ginsenoside derivatives with different glycosides and double bond position on anti-aging bioactivities

   Journal of ginseng research·9 May 2025