Ganciclovir

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 2 more
  • Animals1

Outcomes

2

Intervertebral disc degeneration

downin mice1

1 study
  1. Ganciclovir decreases intervertebral disc degeneration in mice.

    “Systemic clearance of p16INK4a -positive senescent cells mitigates age-associated intervertebral disc degeneration”

    Animalsp16-3MR transgenic miceintervertebral disc

    Systemic clearance of p16INK4a -positive senescent cells mitigates age-associated intervertebral disc degeneration

    Aging cell21 Mar 2019

More on Intervertebral disc degeneration

Proteoglycan matrix content

upin mice1

1 study
  1. Ganciclovir increases proteoglycan matrix content in mice.

    “increased overall proteoglycan matrix content along with improved histological disc features”

    Animalsp16-3MR mice treated with ganciclovirintervertebral disc

    Systemic clearance of p16INK4a -positive senescent cells mitigates age-associated intervertebral disc degeneration

    Aging cell21 Mar 2019

More on Proteoglycan matrix content

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