Skin carcinogenesis

1. Ganciclovir inhibits skin carcinogenesis in mice.

   “carcinogen-initiated tumor development was greatly inhibited when senescent fibroblasts were eliminated in K6/ODC; p16-3MR mice.”

   Animalsin K6/ODC; p16-3MR mice with ganciclovir elimination of senescent fibroblasts

   Elevated Polyamine Metabolism Activates Fibroblasts via GCN2 Activation and Generates Senescent Fibroblasts to Promote Tumor Formation and Progression

   Molecular carcinogenesis·Aug 19, 2025

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1. Ultraviolet radiation raises the risk of skin carcinogenesis in humans.

   “photoaging affects cutaneous biology, increasing the risk of skin carcinogenesis.”

   Review

   Skin Cancer Microenvironment: What We Can Learn from Skin Aging?

   International journal of molecular sciences·Sep 13, 2023

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1. DDB2 raises the risk of skin carcinogenesis in mice.

   “Consistent with the human disease (XP-E), the DDB2-/- mice were susceptible to UV-induced skin carcinogenesis.”

   AnimalsDdb2 deficiency, following UV irradiationskin

   Tumor-prone phenotype of the DDB2-deficient mice

   Oncogene·Jan 13, 2005

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