Fucoxanthin

1. Fucoxanthin decreases CDKN1A in mice.

   “dietary 0.01% fucoxanthin diminished the hepatic, renal, and muscular expression of the aging marker Cdkn1a (p21).”

   Animalsdietary0.01%

   Dietary fucoxanthin alleviates skin aging and modulates systemic aging markers in naturally aged C57BL/6J mice

   The Journal of nutritional biochemistry·16 Feb 2026

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1. Fucoxanthin decreases CDKN2A in mice.

   “These improvements were accompanied by a reduced expression of senescence-related genes Cdkn2a (p16) and Cdkn1a (p21)”

   Animalsdietaryskin0.01 and 0.1%

   Dietary fucoxanthin alleviates skin aging and modulates systemic aging markers in naturally aged C57BL/6J mice

   The Journal of nutritional biochemistry·16 Feb 2026

More on CDKN2A

1. Fucoxanthin decreases wrinkle formation in mice.

   “both concentrations of fucoxanthin attenuated the age-dependent elevation of trans-epidermal water loss (TEWL) and the wrinkle formation.”

   Animalsdietaryskin0.01 and 0.1%

   Dietary fucoxanthin alleviates skin aging and modulates systemic aging markers in naturally aged C57BL/6J mice

   The Journal of nutritional biochemistry·16 Feb 2026

1. Fucoxanthin decreases trans-epidermal water loss in mice.

   “both concentrations of fucoxanthin attenuated the age-dependent elevation of trans-epidermal water loss (TEWL) and the wrinkle formation.”

   Animalsdietaryskin0.01 and 0.1%

   Dietary fucoxanthin alleviates skin aging and modulates systemic aging markers in naturally aged C57BL/6J mice

   The Journal of nutritional biochemistry·16 Feb 2026

More on Trans-epidermal water loss

1. Fucoxanthin decreases lipid peroxidation in rats.

   “Fucoxanthin was detected and shown to decrease lipid peroxidation in the brains of the animals supplemented with fucoxanthin.”

   Animalsbrain1 mg/kg4 weeksmalesn = 6

   Oral supplementation of fucoxanthin regulates gene expression in the brain of middle-aged rats

   The British journal of nutrition·3 Sep 2025

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1. Fucoxanthin protects against oxidative stress and ROS signalling in rat cells.

   “Treatment with fucoxanthin protected rat primary hippocampal neurons against oxidative stress and ageing in vitro.”

   Cellsin vitro

   Oral supplementation of fucoxanthin regulates gene expression in the brain of middle-aged rats

   The British journal of nutrition·3 Sep 2025

More on Oxidative stress and ROS signalling

1. Fucoxanthin decreases IL-6 in mice (-13-14%).

   “a decrease in proinflammatory cytokines IL-6, TNF-α and MCP-1 by 13-14% was recorded compared to the control group”

   Animalscompared to the control group

   Search for a new geroprotector: study of the effect of fucoxanthin on the main markers of aging in mice

   Advances in gerontology = Uspekhi gerontologii·1 Jan 2025

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1. Fucoxanthin increases total antioxidant activity in mice (+24%).

   “an increase in the total antioxidant activity of blood plasma by 24%”

   Animalscompared to the control groupblood plasma

   Search for a new geroprotector: study of the effect of fucoxanthin on the main markers of aging in mice

   Advances in gerontology = Uspekhi gerontologii·1 Jan 2025

More on Total antioxidant activity

1. Fucoxanthin decreases malondialdehyde in mice (-17%).

   “a decrease in the concentration of malondialdehyde in the liver by 17%”

   Animalscompared to the control groupliver

   Search for a new geroprotector: study of the effect of fucoxanthin on the main markers of aging in mice

   Advances in gerontology = Uspekhi gerontologii·1 Jan 2025

More on Malondialdehyde